Evidence map›Paper›PMID 41128781›Full record

ArticlePediatric radiology2026

Magnetic resonance imaging-based assessment of hippocampal glutamate and morphometric changes in preterm infants at term-equivalent age with low birth weight.

Lumeng Xu, He Gong, Qingfa Ren, Shuyuan Xia, Minglong Li, Hongyu Ning, Quanyuan Liu, Caixia Yang, Jing Wang, Zhijie Yin and 1 more

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Article in Pediatric radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Lumeng XuSchool of Medical Imaging, Binzhou Medical University, Yantai, China.
He GongSchool of Medical Imaging, Binzhou Medical University, Yantai, China.
Qingfa RenSchool of Medical Imaging, Binzhou Medical University, Yantai, China.
Shuyuan XiaDepartment of Radiology, Binzhou Medical University Hospital, Binzhou, China.
Minglong LiSchool of Medical Imaging, Binzhou Medical University, Yantai, China.
Hongyu NingSchool of Medical Imaging, Binzhou Medical University, Yantai, China.
Quanyuan LiuDepartment of Radiology, Binzhou Medical University Hospital, Binzhou, China.
Caixia YangSchool of Medical Imaging, Binzhou Medical University, Yantai, China.
Jing WangDepartment of Radiology, Binzhou Medical University Hospital, Binzhou, China.
Zhijie YinDepartment of Radiology, Binzhou Medical University Hospital, Binzhou, China. yzj33@126.com.
Xianglin LiSchool of Medical Imaging, Binzhou Medical University, Yantai, China. xlli@bzmc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow birth weight and preterm infants may have higher risks of poor health. As the key brain region for learning and memory, normal development of the hippocampus is crucial for the cognitive abilities of preterm infants.

objectiveThis study aimed to analyze hippocampal glutamate (Glu) levels and morphometric changes in preterm infants at term-equivalent age (TEA) with different birth weights. MATERIALS AND

methodsEighty-seven infants (23 full-term infants and 64 preterm infants) born between 2023 and 2025, underwent magnetic resonance imaging (MRI) at TEA. Glutamate chemical exchange saturation transfer (GluCEST) MRI and 3D-SPACE were used to assess hippocampal Glu levels and morphometric changes. The preterm cohort was categorized by birth weight: preterm infants born at extremely and very low birth weight (Group 1), preterm infants born at low birth weight (Group 2) and preterm infants born at normal birth weight (Group 3). Full-term infants born at normal birth weight (Group 4) were included as controls.

resultsGroup 1 exhibited elevated Glu levels, Group 2 showed intermediate Glu levels. In infants with normal birth weight, preterm at TEA have higher glutamate levels than full-term infants. No differences were observed in the bilateral hippocampal Glu levels within each group. The bilateral hippocampal volume, surface area, and long diameter in Group 1 were all significantly smaller than those in Group 3. Morphological analysis revealed rightward hippocampal asymmetry in all preterm groups.

conclusionBirth weight significantly influences hippocampal glutamate levels and morphology in preterm infants. These findings offer new insights into the metabolic variations in preterm neurodevelopment.

Indexed as

Glutamic AcidHippocampusInfant, Low Birth WeightInfant, PrematureMagnetic Resonance ImagingFemaleHumansInfant, NewbornMaleGlutamic AcidBirth weightGlutamateHippocampusMagnetic resonance imagingPreterm infants

Identifiers

PMID41128781

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