ArticleMolecular biology reports2025
Impact of IFITM3 rs12252 and IFNAR2 rs2236757 SNP polymorphisms on influenza virus infection outcomes in Moroccan patients.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundSeasonal influenza is a crucial public health concern. Recent populationalstudies, confirmed the involvement of several signaling proteins on the outcome of theinfection. The IFITM3 and IFNAR2 variants, play acritical role in the host’sinnate immune response.The current study aims to evaluate the association between the IFITM3 rs12252 and IFNAR2rs2236757 variants with the risk of developing Severe Acute Respiratory Infection (SARI) orInfluenza-Like Illness (ILI) in Moroccan patients infected with influenza virus.
methodsA comparative case-control study was conducted based on an existing sentinel system forvirological surveillance of influenza respiratory viruses. From August 25, 2023, to April 17,2024, a total of 1,925 nasopharyngeal swabs were collected from patients who met the World Health Organization case definitions for SARI and ILI. A group of healthy individuals were included as a control group. Influenza infection was diagnosed using qRT-PCR in accordance with the US-CDC protocol. Genotyping of the IFITM3 rs12252 and IFNAR2 rs2236757 variant was carried-out using TaqMan SNP Genotyping Assays.did not find it Statistical data analysis was performed using SNPStats and MedCalc software.
resultsGenetic analysis revealed a significant association between the IFITM3 rs12252 variants and the severe syndrome (SARI). Carriers of the AG/GG genotypes had a significantly higher risk of hospitalization for SARI patients compared to those with other genotypes; the adjusted odds ratio (OR) ranged from 2.66 to 12.66 (p-value < 0.0001 and 0.0003). In contrast, no significant association was found between IFNAR2 rs2236757variant and either syndrome.
conclusionsA strong association of the IFITM3 rs12252 variant was confirmed among SARI patients, but not among ILI ones. The IFNAR2 rs2236757, however, did not show any association between flu infection and the clinical outcome.
Indexed as
Identifiers
41128776What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.