Evidence map›Paper›PMID 41128634›Full record

ArticleThe Journal of pathology2025

Lactate-mediated activation of GPR81 regulates BCR/Abl protein expression in chronic myeloid leukemia cells selected under low oxygen tension.

Giulio Menegazzi, Dayana Desideri, Alessio Biagioni, Elisabetta Rovida, Persio Dello Sbarba, Silvia Peppicelli

Abstract read
In one paragraph

Article in The Journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Giulio MenegazziDepartment of Experimental and Clinical Biomedical Sciences, Università degli Studi di Firenze, Florence, Italy.
Dayana DesideriDepartment of Experimental and Clinical Biomedical Sciences, Università degli Studi di Firenze, Florence, Italy.
Alessio BiagioniDepartment of Experimental and Clinical Biomedical Sciences, Università degli Studi di Firenze, Florence, Italy.
Elisabetta RovidaDepartment of Experimental and Clinical Biomedical Sciences, Università degli Studi di Firenze, Florence, Italy.
Persio Dello SbarbaDepartment of Experimental and Clinical Biomedical Sciences, Università degli Studi di Firenze, Florence, Italy.
Silvia PeppicelliDepartment of Experimental and Clinical Biomedical Sciences, Università degli Studi di Firenze, Florence, Italy.ORCID https://orcid.org/0000-0001-6459-0458

Funding

Associazione Italiana per la Ricerca sul Cancro IG23607Fondazione PezcollerFondazione Umberto VeronesiRegione Toscana
6 · The paper itself

Abstract

Chronic myeloid leukemia (CML) is a stem cell-driven neoplasia characterized by the expression of the constitutively active tyrosine kinase (TK) BCR/Abl. Under low oxygen, a condition that characterizes stem cell niches (SCNs) in vivo, the oncogenic BCR/Abl

Indexed as

Fusion Proteins, bcr-ablLactic AcidLeukemia, Myelogenous, Chronic, BCR-ABL PositiveNeoplastic Stem CellsOxygenReceptors, G-Protein-CoupledCell Line, TumorDrug Resistance, NeoplasmGene Expression Regulation, LeukemicGlycolysisHumansK562 CellsMonocarboxylic Acid TransportersFusion Proteins, bcr-ablHCAR1 protein, humanLactic AcidMonocarboxylic Acid TransportersOxygenReceptors, G-Protein-CoupledBCR/Ablchronic myeloid leukemiaGPR81lactatelow oxygenstem cell niche

Identifiers

PMID41128634
PMCPMC12596911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.