Evidence map›Paper›PMID 41128493›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2026

Factors Associated With Preference for Long-Acting Injectable Versus Daily Oral Antiretroviral Therapy Among People With HIV: Findings From the SELIGO Study.

Deanna Kerrigan, Carolina Ruiz, Breana J Uhrig Castonguay, Humberto Rodriguez Gonzalez, Kenneth Mayer, Julia Fleming, Matteo Peretti, Edward Cachay, Laura Bamford, Robert Agans and 3 more

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Deanna KerriganDepartment of Prevention and Community Health, George Washington University Milken Institute School of Public Health, Washington, DC.
Carolina RuizDepartment of Health Behavior, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Breana J Uhrig CastonguayDepartment of Prevention and Community Health, George Washington University Milken Institute School of Public Health, Washington, DC.
Humberto Rodriguez GonzalezDepartment of Health Behavior, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Kenneth MayerFenway Health, Boston, MA.
Julia FlemingFenway Health, Boston, MA.
Matteo PerettiFenway Health, Boston, MA.
Edward CachayDepartment of Infectious Diseases, Mayo Clinic, Scottsdale, AZ.
Laura BamfordUniversity of California at San Diego, San Diego, CA.
Robert AgansDepartment of Biostatistics, Gillings Global School of Public Health, University of North Carolina, Chapel Hill, NC.
Clare BarringtonDepartment of Health Behavior, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Stephen ColeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
David WohlDepartment of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC; and.

Funding

Patient and Provider perspectives on long acting injectable ARTR01MH118955 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARRINGTON, CLARE L, KERRIGAN, DEANNA L · 2019 to 2023
$3.0M
Training Program in Approaches to Address Social-Structural Factors Related to HIV Intersectionally (TASHI)T32MH130247 · NIMH · GEORGE WASHINGTON UNIVERSITY · PI Ingrid Alisa Bowleg, Deanna L Kerrigan · 2022 to 2026
$965k
National Institutes of Health (US) R01MH118955NIMH NIH HHS R01 MH118955NIMH NIH HHS T32 MH130247
6 · The paper itself

Abstract

backgroundHIV outcomes in people with HIV (PWH) are suboptimal and inequitably distributed in the United States. Long-acting injectable antiretroviral therapy (LAI-ART) has potential to make important contributions to improving HIV outcomes and quality of life for PWH.

methodsThe SELIGO Study used a 1-time, 20-minute survey of 801 PWH from the Center for AIDS Research Network of Integrated Clinical Systems cohort in 3 US cities (Boston, MA; Chapel Hill, NC; San Diego, CA) that included 54 items. Using multinomial and binary logistic regression, we assessed factors associated with LAI-ART versus daily oral ART preferences.

resultsMost participants were cisgender men (82.3%); 57.0% identified as racial and/or ethnic minorities; mean years of age, 52.2; mean years living with HIV, 18.1; 2.8% were using LAI-ART. Compared with daily oral ART, 56.9% preferred LAI-ART administered monthly, and 68.0% preferred LAI-ART administered every 2 months. Factors associated with greater odds of LAI-ART preference included medication/contraception injection experience, pill burden, no medication other than ART, 4 or more clinic visits per year, detectable viral load, reporting a higher number of HIV treatment considerations, and identifying as Black. Factors associated with decreased odds of LAI-ART preference included older age, identifying as neither gay nor straight, living > 1 hour from the clinic, and considerable/extreme needle fear.

conclusionsFindings demonstrate that although there is considerable interest in LAI-ART, HIV treatment modality preferences are multifaceted. Shared decision making can ensure that conversations about ART options consistently address specific factors across diverse groups to facilitate equitable LAI-ART uptake.

Indexed as

Anti-HIV AgentsAnti-Retroviral AgentsHIV InfectionsPatient PreferenceAdministration, OralAdultDelayed-Action PreparationsFemaleHumansInjectionsMaleMiddle AgedSurveys and QuestionnairesUnited StatesAnti-HIV AgentsAnti-Retroviral AgentsDelayed-Action Preparationsantiretroviral therapyHIVlong-acting injectablemodalitiespreferencestreatment

Identifiers

PMID41128493
PMCPMC12966991

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.