Evidence map›Paper›PMID 41128429›Full record

ArticleEmerging microbes & infections2025

Emergence, evolution and temporal spread of ceftriaxone-resistant

Chi Zhang, Yang Yang, Bangyong Zhu, Xiaozheng Tang, Na Zhong, Youwei Wang, Zhijun Zeng, Huichao Chen, Xinyi Lu, Cansheng Zhu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chi ZhangNHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Respiratory Disease Pathogenomics, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Yang YangDepartment of Clinical Laboratory, Shanghai Skin Disease Hospital, Shanghai, People's Republic of China.
Bangyong ZhuDepartment of Clinical Laboratory, Dermatology Institute of Guangxi Zhuang Autonomous Region, Nanning, People's Republic of China.
Xiaozheng TangDepartment of Clinical Laboratory, The Fifth People's Hospital of Hainan Province, Haikou, People's Republic of China.
Na ZhongDepartment of Clinical Laboratory, The Fifth People's Hospital of Hainan Province, Haikou, People's Republic of China.
Youwei WangDepartment of Laboratory Medicine and Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Zhijun ZengInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, People's Republic of China.
Huichao ChenInstitute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, People's Republic of China.
Xinyi LuInstitute for AIDS/STD Control and Prevention, Shaanxi Provincial Centre for Disease Control and Prevention, Xian, People's Republic of China.
Cansheng ZhuDepartment of Clinical Laboratory, Shaanxi Provincial Centre for Disease Control and Prevention, Xian, People's Republic of China.
Ruizha ShadehanInstitute for AIDS/STD Control and Prevention, Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi, People's Republic of China.
Wenling CaoDepartment of Clinical Laboratory, Guangzhou Dermatology Hospital, Guangzhou, People's Republic of China.
Daniel GolparianWHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Weiming GuDepartment of Clinical Laboratory, Shanghai Skin Disease Hospital, Shanghai, People's Republic of China.
Magnus UnemoWHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Junping PengNHC Key Laboratory of Systems Biology of Pathogens, Key Laboratory of Respiratory Disease Pathogenomics, Key Laboratory of Pathogen Infection Prevention and Control (Ministry of Education), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance to the last treatment option for gonorrhoea, ceftriaxone is a major public health concern globally, which poses a serious threat to the currently recommended ceftriaxone monotherapy. We elucidate the emergence, evolution and temporal spread of ceftriaxone-resistant gonococcal strains in China, using whole-genome sequencing of 357 ceftriaxone-resistant isolates from eight provinces during 2002-2022. We describe distinct differences between ceftriaxone-resistant gonococcal strains in China and global isolates. The resistance levels for the 357 isolates for cefixime, azithromycin, ciprofloxacin, benzylpenicillin, tetracycline, and spectinomycin were 92.4%, 17.0%, 100%, 84.9%, 92.7%, and 0.8%, respectively. Before 2019, ceftriaxone-resistant isolates in China mainly harboured non-mosaic

Indexed as

Anti-Bacterial AgentsCeftriaxoneDrug Resistance, BacterialGonorrheaNeisseria gonorrhoeaeChinaEvolution, MolecularGenome, BacterialHumansMicrobial Sensitivity TestsMultilocus Sequence TypingPhylogenyRetrospective StudiesWhole Genome SequencingAnti-Bacterial AgentsCeftriaxoneceftriaxone-resistanceFC428 cloneNeisseria gonorrhoeaetemporal phylogenywhole-genome sequencing

Identifiers

PMID41128429
PMCPMC12599174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.