Evidence map›Paper›PMID 41128409›Full record

ArticleHistology and histopathology2026

Histologic evaluation of the effect of grape seed oil and ferric sulfate in pulpotomy applied to molar teeth of rats: An

Kamile Nur Tozar, Günay Yapici Yavuz, Ebru Elibol Annaç, Aydın Keskinrüzgar, Muhammed Baybatmaz, Ilknur Öz, Mesut Tozar, Osman Küçükkelepçe

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Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Kamile Nur TozarDepartment of Pediatric Dentistry, Antalya Oral and Dental Health Hospital, Antalya, Turkey.
Günay Yapici YavuzDepartment of Oral and Maxillofacial Surgery, Adıyaman Oral and Dental Health Hospital, Adıyaman, Turkey.
Ebru Elibol AnnaçDepartment of Histology and Embryology, Adıyaman University, Adıyaman, Turkey.
Aydın KeskinrüzgarOral and Maxillofacial Surgery, Private Hospital, Gaziantep, Turkey.
Muhammed BaybatmazDepartment of Pediatric Dentistry, Adıyaman University, Adıyaman, Turkey.
Ilknur ÖzDepartment of Histology and Embryology, Başkent University, Ankara, Turkey.
Mesut TozarDepartment of Otorhinolaryngology, Kepez State Hospital, Antalya, Turkey.
Osman KüçükkelepçeAdiyaman Provincial Health Directorate, Adıyaman, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to examine the healing potential of Grape Seed Oil (GSO) on the pulp tissue that remains following pulpotomy treatment. MATERIALS AND

methodsThe upper first molars of 18 two-month-old male Wistar albino rats were divided into two groups according to the material used in pulpotomy treatment. In the pulpotomy treatment group, GSO was used, while ferric sulfate (FS) was used in the control group. The rats were euthanized at 24 hours, 15 days, and 30 days following treatment. Histopathological evaluation of the samples was conducted using the hematoxylin-eosin staining method. The evaluation was conducted to ascertain alterations in connective tissue, vascular changes (i.e., angiopathic findings), inflammation, and hemorrhagic findings in the pulp. The data obtained in this study were analyzed with the IBM SPSS Statistics Version 21 software program.

resultsIn the present study, it was observed that the inflammatory response in the GSO group was higher than that in the FS group at 24 hours. The investigation revealed that the vascular response exhibited a higher magnitude in the GSO group compared to the FS group at 24 hours and at day 15. However, this response exhibited a decline at day 30. Despite an increase in hemorrhaging on the 15th day in the GSO group, this phenomenon decreased over time.

conclusionsIt has been observed that GSO is a biocompatible material that can be used as an alternative to FS in pulpotomy treatment.

Indexed as

Dental PulpFerric CompoundsGrape Seed ExtractMolarPulpotomyWound HealingAnimalsMaleRatsRats, WistarFerric Compoundsferric sulfateGrape Seed Extract

Identifiers

PMID41128409

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.