ArticlePhysiological reports2025
Myrtus communis essential oil mitigates bisphenol A-induced reproductive and lipidomic alterations in a male rat model.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Article
- Protective Role ofFood science & nutrition · 2026Article
- Protective Effects ofAntioxidants (Basel, Switzerland) · 2026Article
- Protective and Detoxifying Effects of Myrtus communis Essential Oil Against Bisphenol A-Induced Metabolic Disturbances in Wistar Rats.BioMed research international · 2026Article
- Myrtus communis essential oil mitigates bisphenol A-induced reproductive and lipidomic alterations in a male rat model.Physiological reports · 2025Article
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Authors and funding
7 authors.
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Abstract
Bisphenol A (BPA), a widespread endocrine disruptor, induces male reproductive toxicity by impairing spermatogenesis and altering hormonal homeostasis. This study investigated the protective effects of Myrtus communis essential oil (EOMC) or vitamin E (Vit E) in adult male rats exposed to BPA (100 mg/kg/day). BPA administration led to testicular damage, decreased sperm quality, hormonal imbalance, oxidative stress, and changes in lipid metabolism. Vit E preserved seminiferous tubule structure and reduced the presence of immature germ cells, though partial disruption of spermatogenesis persisted. EOMC displayed dose-dependent protective effects at 50, 100, and 200 mg/kg. At the highest dose, EOMC improved sperm parameters, restored testicular histology, preserved membrane phospholipid composition, and normalized levels of steroid hormones including testosterone, estradiol, progesterone, and cortisol. It also prevented body weight loss induced by BPA. Although Vit E provided better protection of tubule structure, EOMC at 200 mg/kg offered broader benefits across multiple reproductive parameters. These findings highlight the therapeutic potential of high-dose EOMC in mitigating BPA-induced male reproductive toxicity and support its use as a natural protective agent.
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