Evidence map›Paper›PMID 41128369›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2025

Association of Primary Sclerosing Cholangitis With HLA-C*07:02 in a Japanese Population.

Tatsuya Okamoto, Hideaki Okajima, Masashi Kadohisa, Miki Yamamoto, Elena Yukie Uebayashi, Shinya Okumura, Katsunori Sakamoto, Takashi Ito, Etsuro Hatano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Postoperative detection ofTransplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  2. Association of Primary Sclerosing Cholangitis With HLA-C*07:02 in a Japanese Population.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tatsuya OkamotoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hideaki OkajimaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Masashi KadohisaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Miki YamamotoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Elena Yukie UebayashiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shinya OkumuraDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Katsunori SakamotoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-6431-0011
Takashi ItoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-5892-8317
Etsuro HatanoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0003-3407-1918

Funding

ISIZUE 2025 of Kyoto University 0700145010
6 · The paper itself

Abstract

BACKGROUND AND

aimsPrimary sclerosing cholangitis (PSC) is a progressive, refractory liver disease often requiring liver transplantation (LT). The association between the disease onset and specific human leukocyte antigen (HLA) typing has been noted, but its relevance in the Japanese population is unknown.

methodsThe HLA 5 locus (HLA-A, B, C, DRB1 and DQB1) 4-digit genotyping results of 31 patients with progressive PSC who underwent LT at our institution were compared to those of 873 healthy Japanese controls.

resultsHLA-B*07:02 (p-corrected [p

conclusionsHLA-C*07:02 is vulnerable to PSC aggravation in the Japanese population.

Indexed as

Cholangitis, SclerosingGenetic Predisposition to DiseaseHLA-C AntigensAdultAgedAllelesCase-Control StudiesColitis, UlcerativeEast Asian PeopleFemaleGenotypeHLA-DRB1 ChainsHumansJapanLiver TransplantationMaleHLA-C AntigensHLA-DRB1 Chainshuman leukocyte antigen (HLA)liver transplantationprimary sclerosing cholangitis (PSC)ulcerative colitis (UC)

Identifiers

PMID41128369
PMCPMC12548302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.