ArticleCytoskeleton (Hoboken, N.J.)2026
The C-Terminal Regions of TRAK Proteins Contain MIRO-Independent Mitochondrial Localization Domains.
Article in Cytoskeleton (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo.Science (New York, N.Y.) · 2026Article
- The C-Terminal Regions of TRAK Proteins Contain MIRO-Independent Mitochondrial Localization Domains.Cytoskeleton (Hoboken, N.J.) · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Current models suggest that MIRO GTPases anchor cytoskeletal motors to the mitochondrial outer membrane (MOM). However, our previous findings indicate that the unconventional myosin, MYO19, interacts with MIRO weakly and that a MIRO-independent MOM-localizing domain interacts more tightly with the MOM. To test the hypothesis that other MIRO interactors may also have MIRO-independent MOM binding, we examined interactions between TRAK proteins (microtubule motor-mitochondria adaptor proteins) and the MOM via quantitative fluorescence microscopy and steady-state kinetic approaches. Using GFP-TRAK truncations expressed in MIRO1-2 double knockout mouse embryonic fibroblasts, we identified a MIRO-independent mitochondrial-binding domain in the C-terminus of TRAK1 and TRAK2, with a MOM localization pattern similar to what we observed for full-length GFP-TRAK proteins. The MIRO-binding domains (MBD) of the TRAK proteins were only able to localize to mitochondria when MIRO is expressed. Importantly, fluorescence recovery after photobleaching (FRAP) demonstrated that the steady-state kinetics of TRAK
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.