ArticleJournal of the American Heart Association2025
Seizures in Infants With Congenital Heart Disease: A National Cohort Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Seizures in congenital heart disease: risks, outcomes, and birth cohort data from China.Frontiers in pediatrics · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfants with congenital heart disease (CHD) may have an increased risk of seizures.
methodsWe analyzed the US National Inpatient Sample Database (2016-2020). We included infants with CHD who developed seizures. We excluded premature infants <34 weeks and infants with central nervous system or genetic disorders. CHD was classified into shunt, cyanotic, left-sided, or single ventricle lesions. We compared demographics, clinical characteristics, and outcomes between CHD infants with versus without seizures.
resultsInfants in the weighted sample (19 089 414) met our inclusion criteria. Of that group, 42.4% of patients were female and 45.8% were White. There were 417 053 (2.2%) patients identified with CHD, and 47 501 (0.25%) patients had at least 1 episode of seizure. Seizures occurred in 1.8% of infants with any CHD versus 0.21% of infants with no CHD (adjusted odds ratio, 5.7 [95% CI, 5.5-5.8];
conclusionsInfants with CHD have higher odds of experiencing seizure. Cyanotic CHD had the lowest incidence of seizure, while patients with single ventricle experienced the highest risk. Having seizures was associated with longer hospital stay and higher odds of mortality. This information may help in counseling families about the neurologic outcomes of infants with CHD.
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