Evidence map›Paper›PMID 41128106›Full record

ArticleChemPlusChem2025

A pH-Responsive Synthetic Receptor for Switchable Binding of Carbohydrates.

Francesco Milanesi, Giona Corti, Andrea Baldi, Stefano Roelens, Oscar Francesconi

Abstract read
In one paragraph

Article in ChemPlusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francesco MilanesiDepartment of Chemistry "Ugo Schiff", DICUS, Università degli Studi di Firenze, Via della Lastruccia 13, I-50019, Sesto Fiorentino Firenze, Italy.ORCID 0000-0002-1981-5811
Giona CortiDepartment of Chemistry "Ugo Schiff", DICUS, Università degli Studi di Firenze, Via della Lastruccia 13, I-50019, Sesto Fiorentino Firenze, Italy.
Andrea BaldiDepartment of Chemistry "Ugo Schiff", DICUS, Università degli Studi di Firenze, Via della Lastruccia 13, I-50019, Sesto Fiorentino Firenze, Italy.ORCID 0000-0001-8372-1855
Stefano RoelensDepartment of Chemistry "Ugo Schiff", DICUS, Università degli Studi di Firenze, Via della Lastruccia 13, I-50019, Sesto Fiorentino Firenze, Italy.ORCID 0000-0002-9763-3263
Oscar FrancesconiDepartment of Chemistry "Ugo Schiff", DICUS, Università degli Studi di Firenze, Via della Lastruccia 13, I-50019, Sesto Fiorentino Firenze, Italy.ORCID 0000-0002-6155-4926

Funding

MUR-Dipartimenti di Eccellenza 2023-2027 DICUS 2.0
6 · The paper itself

Abstract

Stimuli-responsive, water-soluble synthetic receptors are key to advancing dynamic molecular recognition in aqueous environments, with implications for self-assembly, molecular machines, and biomedical systems. Herein, a macrocyclic receptor is reported that exhibits pH-dependent binding properties toward saccharides in water, in that it displays markedly different affinities between alkaline and neutral conditions. Spectroscopic and binding studies reveal that the degree of protonation of the solubilizing groups modulates the receptor self-association phenomena, together with concomitant substantial loss of binding ability. This work highlights a rare example of a pH-switchable carbohydrate receptor operating in water and underscores the potentials of such system in the design of smart, responsive molecular architectures.

Indexed as

CarbohydratesMacrocyclic CompoundsReceptors, ArtificialBinding SitesHydrogen-Ion ConcentrationWaterCarbohydratesMacrocyclic CompoundsReceptors, ArtificialWateraggregationcarbohydratesmolecular recognitionmolecular switchsynthetic receptor

Identifiers

PMID41128106
PMCPMC12701286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.