Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Shanna HamiltonDepartment of Physiology and Cell Biology (S.H., R.T., R.V., F.P., S.G., A.E.B., D.T.), The Ohio State University, Columbus.ORCID 0000-0003-1016-4706
Radmila TerentyevaDepartment of Physiology and Cell Biology (S.H., R.T., R.V., F.P., S.G., A.E.B., D.T.), The Ohio State University, Columbus.ORCID 0000-0002-0133-3515
Roland VeressDepartment of Physiology and Cell Biology (S.H., R.T., R.V., F.P., S.G., A.E.B., D.T.), The Ohio State University, Columbus.ORCID 0000-0001-8733-7228
Fruzsina PergerDepartment of Physiology and Cell Biology (S.H., R.T., R.V., F.P., S.G., A.E.B., D.T.), The Ohio State University, Columbus.
Zuzana NichtovaDepartment of Pathology, Anatomy and Cell Biology, MitoCare Center, Thomas Jefferson University, Philadelphia, PA (Z.N., G.C.).
Mark BannisterFaculty of Medicine, Health and Life Sciences, Swansea University, Wales, United Kingdom (M.B., C.H.G.).
Jinxi WangDivision of Cardiovascular Medicine, Department of Internal Medicine, Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa (J.W.).ORCID 0000-0002-7349-6153
Sage QuiggleDepartment of Physiology and Cell Biology (S.H., R.T., R.V., F.P., S.G., A.E.B., D.T.), The Ohio State University, Columbus.
Rachel BattershellDepartment of Cellular and Molecular Medicine, The University of Arizona, Tucson (S.H., S.Q., R.B.).ORCID 0009-0002-5207-0388
Matthew W GorrDivision of Cardiac Surgery, Department of Surgery, College of Medicine (M.W.G.), The Ohio State University, Columbus.ORCID 0000-0001-7561-6481
Sandor GyörkeCollege of Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (S.H., R.T., R.V., F.P., M.W.G., S.G., A.E.B., D.T.).
Bum-Rak ChoiDepartment of Medicine, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence (B.-R.C.).ORCID 0000-0001-7319-3219
Christopher H GeorgeFaculty of Medicine, Health and Life Sciences, Swansea University, Wales, United Kingdom (M.B., C.H.G.).ORCID 0000-0001-9852-1135
Andriy E BelevychDepartment of Physiology and Cell Biology (S.H., R.T., R.V., F.P., S.G., A.E.B., D.T.), The Ohio State University, Columbus.ORCID 0000-0002-1272-5784
György CsordásDepartment of Pathology, Anatomy and Cell Biology, MitoCare Center, Thomas Jefferson University, Philadelphia, PA (Z.N., G.C.).ORCID 0000-0003-3156-1460
Dmitry TerentyevDepartment of Physiology and Cell Biology (S.H., R.T., R.V., F.P., S.G., A.E.B., D.T.), The Ohio State University, Columbus.ORCID 0000-0002-9530-7384
Funding
The mechanisms and roles of mitochondria dysfunction in cardiac arrhythmogenesisR01HL166604 · NHLBI · OHIO STATE UNIVERSITY · PI Dmitry A Terentyev · 2023 to 2026
$2.8M
Novel Mechanisms of Regulation of SK channels: Implications for Cardiac ArrhythmiaR01HL142588 · NHLBI · OHIO STATE UNIVERSITY · PI TERENTYEV, DMITRY A · 2019 to 2022
backgroundMitochondrial dysfunction caused by abnormally high RyR2 (ryanodine receptor) activity is a common finding in cardiovascular diseases. Mechanisms linking RyR2 gain of function with mitochondrial remodeling remain elusive. We hypothesized that RyR2 hyperactivity in cardiac disease increases [Ca
methodsWe generated a highly arrhythmogenic rat model of catecholaminergic polymorphic ventricular tachycardia, induced by RyR2 gain-of-function mutation S2236L(Ser2336Leu)
resultsWe found altered mitochondrial cristae structure, increased IMS-[Ca
conclusionsOur data suggest that RyR2 hyperactivity contributes to mitochondrial structural damage by promoting an increase in IMS-[Ca
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Increased Intermembrane Space [Ca · full record | OpenQuestion