Evidence map›Paper›PMID 41127870›Full record

ReviewBrain, behavior, & immunity - health2025

Break free from cognitive impairment: The magic of exercise-induced molecules.

Wenbo Liu, Hui Zhang, Qiuting Zeng, Wenlan Cai, Yunfeng Rui, Jie Sun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Bioenergetics of the combat sports brain: Between risk and resilience.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenbo LiuDepartment of Anesthesiology & Key Laboratory of Clinical Science and Research, Department of Anesthesiology, Zhongda, Hospital, Medical School, Southeast University, China.
Hui ZhangDepartment of Anesthesiology & Key Laboratory of Clinical Science and Research, Department of Anesthesiology, Zhongda, Hospital, Medical School, Southeast University, China.
Qiuting ZengDepartment of Anesthesiology & Key Laboratory of Clinical Science and Research, Department of Anesthesiology, Zhongda, Hospital, Medical School, Southeast University, China.
Wenlan CaiDepartment of Anesthesiology & Key Laboratory of Clinical Science and Research, Department of Anesthesiology, Zhongda, Hospital, Medical School, Southeast University, China.
Yunfeng RuiDepartment of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Jie SunDepartment of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

•Exercise-induced molecules regulate cognition via trophic, immune, and metabolic pathways.•Muscle-brain crosstalk contributes to cognitive resilience in aging and neurodegeneration.•CTSB, lactate and others show dual roles-protective yet potentially pathological-depending on context.•Translational perspective: target exercise-mimetic molecules as non-pharmacological options for cognitive disorders.

Indexed as

Cognitive impairmentExerciseMyokinesNeuroinflammationNeuroplasticityNeuroprotection

Identifiers

PMID41127870
PMCPMC12537576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.