ArticleInternational medical case reports journal2025
SAPHO Syndrome Misdiagnosed as Spinal Infection: A Case Series.
Article in International medical case reports journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Costovertebral joint involvement on CT in SAPHO syndrome: distribution and clinical associations.Skeletal radiology · 2026Article
- CT and MRI features of SAPHO syndrome: a report of 6 cases.BMC musculoskeletal disorders · 2026Article
- From misdiagnosis to definitive diagnosis of SAPHO syndrome during a routine health check-up: a case report and literature review.Frontiers in medicine · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare autoinflammatory disorder characterized by osteoarticular symptoms and dermatological lesions. This case series aims to enhance clinical recognition and reduce misdiagnosis by presenting three patients initially misdiagnosed with spinal infection at external hospitals. All cases presented with worsening back pain and recurrent palmoplantar pustulosis (PPP), one of whom also had comorbid psoriasis. Imaging revealed multifocal purely osteolytic lesions in one patient and mixed osteolytic-osteosclerotic changes in the other two. After exclusion of infectious and neoplastic etiologies, all patients were diagnosed with SAPHO syndrome and showed significant improvement with symptomatic treatment. In conclusion, this case series demonstrated that SAPHO syndrome should be considered in patients with back pain and PPP after excluding infection and tumor.
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