Evidence map›Paper›PMID 41127832›Full record

ArticleEnvironment & health (Washington, D.C.)2025

Organophosphate Flame Retardants, Obesity, and Depressive Symptoms among 1019 Young Healthy Men.

Qingqing Xu, Keyi Si, Wenqing Wang, Yaping Li, Yu Zhang, Audrey J Gaskins, Carmen Messerlian, Vicente Mustieles, Cheng-Liang Xiong, An Pan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. An Exploration of Machine Learning Methods in Human Biomonitoring.International journal of environmental research and public health · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qingqing XuDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Keyi SiDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0002-7413-615X
Wenqing WangDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yaping LiState Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei 430030, China.
Yu ZhangDepartments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, United States.ORCID https://orcid.org/0000-0003-4614-7115
Audrey J GaskinsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322,United States.
Carmen MesserlianDepartments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, United States.ORCID https://orcid.org/0000-0002-3884-1492
Vicente MustielesInstituto de Investigación Biosanitaria ibs.GRANADA, Spain, University of Granada, Center for Biomedical Research (CIBM), Spain. Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Granada 18010, Spain.
Cheng-Liang XiongReproductive Medicine Center, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province Human Sperm Bank, Wuhan, Hubei 430030, People's Republic of China.
An PanState Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei 430030, China.
Huiling ShaoDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0009-0009-5711-0132
Surong MeiState Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei 430030, China.ORCID https://orcid.org/0000-0002-9339-5771
Yi-Xin WangDepartment of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID https://orcid.org/0000-0003-4324-2408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organophosphate flame retardants (OPFRs) can increase fat accumulation and exert neurotoxic effects. In this study, we enrolled 1019 young men who provided 3,550 urine samples over a 3-month follow-up period. We measured nine OPFR metabolite concentrations in urine samples and assessed depressive symptoms using the Beck Depression Inventory questionnaire. In the fully adjusted linear regression models, a 2.7-fold increase in urinary diphenyl phosphate (DPHP) concentrations was associated with a 0.44 unit (95% confidence interval (CI): 0.06, 0.82) higher depressive symptom scores. When men were categorized as having any depressive symptoms (score: > 10 vs ≤ 10), Poisson regression models showed an increased risk of depression across DPHP tertiles (

Indexed as

depressive symptomsobesityorganophosphate flame retardantspublic health

Identifiers

PMID41127832
PMCPMC12538333

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.