Evidence map›Paper›PMID 41127825›Full record

ArticleInternational journal of genomics2025

Exploration of the Mechanism of Tongmai Xianxiang in Treating Postherpetic Neuralgia Based on Gas Chromatography-Mass Spectrometry Analysis and Network Pharmacology.

Linglong Qu, Hui Wang, Yufeng Huang, Zhen Gao, Ruichang Song, Shiyu Sun, Pingping Shao, Rukai Wang, Chunlin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linglong QuDepartment of Internal Medicine of Traditional Chinese Medicine, First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China, sdutcm.edu.cn.ORCID https://orcid.org/0009-0009-0224-9647
Hui WangDepartment of Acupuncture-Moxibustion, Zaozhuang Hospital, Dongfang Hospital of Beijing University of Chinese Medicine, Zaozhuang, Shandong, China, bucm.edu.cn.ORCID https://orcid.org/0009-0002-0646-7384
Yufeng HuangDepartment of Pharmacology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China, sdu.edu.cn.ORCID https://orcid.org/0009-0002-3543-8734
Zhen GaoDepartment of Internal Medicine of Traditional Chinese Medicine, First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China, sdutcm.edu.cn.ORCID https://orcid.org/0009-0002-6655-4383
Ruichang SongDepartment of Internal Medicine of Traditional Chinese Medicine, First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China, sdutcm.edu.cn.ORCID https://orcid.org/0009-0005-8925-4799
Shiyu SunDepartment of Internal Medicine of Traditional Chinese Medicine, First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China, sdutcm.edu.cn.ORCID https://orcid.org/0009-0005-2917-2353
Pingping ShaoDepartment of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China, sdutcm.edu.cn.ORCID https://orcid.org/0009-0000-6464-5586
Rukai WangDepartment of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China, sdutcm.edu.cn.ORCID https://orcid.org/0009-0006-0329-2151
Chunlin LiDepartment of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China, sdutcm.edu.cn.ORCID https://orcid.org/0009-0006-9082-1102

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aim of this study is to explore the potential target of Tongmai Xianxiang in the prevention and treatment of postherpetic neuralgia (PHN) by gas chromatography-mass spectrometry (GC-MS) and network pharmacology. Methods: Quantitative analysis using GC-MS was employed to obtain the chemical components of Tongmai Xianxiang, and target site prediction was conducted; PHN-related targets were collected from relevant disease databases; the anti-PHN targets of Tongmai Xianxiang were obtained through network pharmacology methods, and molecular docking was performed on the main targets. Results: A total of 633 active components were screened by GC-MS, corresponding to 772 targets. By searching the disease database, a total of 169 PHN-related disease targets were obtained after removing duplicates. A total of 53 core genes, including SLC6A4, MAOA, DRD2, and ALB, were obtained by intersecting the corresponding target and PHN target. Through molecular docking, the results indicate that ALB has the lowest free binding energy with Z-butylidenephthalide, 2-undecanol, and 1,6,10-dodecatrien-3-OL, 3,7,11-trimethyl-, (E)-. Conclusion: Tongmai Xianxiang can prevent PHN by multitarget, multiprocess, and multipathway. This study provides new ideas and new targets for the intervention of Tongmai Xianxiang in PHN.

Indexed as

Chinese medicine Tongmai Xianxianggas chromatography–mass spectrometrymolecular dockingnetwork pharmacologypostherpetic neuralgia

Identifiers

PMID41127825
PMCPMC12538648

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.