Evidence map›Paper›PMID 41127815›Full record

ArticleJournal of translational autoimmunity2025

Cre-driven tdTomato expression unexpectedly confers resistance to peripheral but not central lupus in dLckCre mice.

Ning Han, Keer Wang, Dan Yang, Mingxuan Han, Xiaoxiao Hou, Zhenghao Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational autoimmunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ning HanInnovation Center for Medical Basic Research of Autoimmune Diseases (National Ministry of Education), TCM Science and Research Center, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, College of Basic Medical Science, Zhejiang Chinese Medical University, Zhejiang, China.
Keer WangInnovation Center for Medical Basic Research of Autoimmune Diseases (National Ministry of Education), TCM Science and Research Center, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, College of Basic Medical Science, Zhejiang Chinese Medical University, Zhejiang, China.
Dan YangInnovation Center for Medical Basic Research of Autoimmune Diseases (National Ministry of Education), TCM Science and Research Center, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, College of Basic Medical Science, Zhejiang Chinese Medical University, Zhejiang, China.
Mingxuan HanInnovation Center for Medical Basic Research of Autoimmune Diseases (National Ministry of Education), TCM Science and Research Center, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, College of Basic Medical Science, Zhejiang Chinese Medical University, Zhejiang, China.
Xiaoxiao HouInnovation Center for Medical Basic Research of Autoimmune Diseases (National Ministry of Education), TCM Science and Research Center, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, College of Basic Medical Science, Zhejiang Chinese Medical University, Zhejiang, China.
Zhenghao XuInnovation Center for Medical Basic Research of Autoimmune Diseases (National Ministry of Education), TCM Science and Research Center, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, College of Basic Medical Science, Zhejiang Chinese Medical University, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Cre-driven tdTomato reporter system is widely used to visualize gene expression and cellular dynamics. Here we tested the impact of the tdTomato reporter system on the progression of both central and peripheral manifestations of systemic lupus erythematosus (SLE) in dLckCre mice. We crossed dLckCre mice with ROSA26

Indexed as

CD4+ T cellsCentral manifestationsPeripheral manifestationsSystemic lupus erythematosusT cell labeling

Identifiers

PMID41127815
PMCPMC12538164

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.