ReviewCureus2025
The Efficacy of Tranexamic Acid in Pediatric Tonsillectomy: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complications of tonsillectomy, such as intraoperative and post-tonsillectomy hemorrhage (PTH), are not uncommon. In children, these may lead to hypovolemic shock, airway obstruction, delayed healing, and infection, among other issues. Tranexamic acid (TXA) is one of several hemostatic agents. However, its efficacy in reducing bleeding during tonsillectomy is not well known. Hence, we aimed to determine whether children undergoing tonsillectomy experienced less perioperative hemorrhage after receiving a preoperative dose of TXA. Two reviewers independently conducted a systematic search of three databases (PubMed, Google Scholar, and the Cochrane Central Register of Controlled Trials [CENTRAL]) until June 2024. This review included all randomized controlled trials (RCTs) involving pediatric patients (<18 years) undergoing tonsillectomy, focusing on studies that evaluated the efficacy of preoperative TXA compared with a control group in reducing intraoperative or postoperative bleeding. The studies varied in outcomes, designs, and sample sizes. A meta-analysis of four studies (n = 380) revealed no significant effect of TXA in reducing intraoperative bleeding (weighted mean difference = -54.44 (95% confidence interval [CI] = -110.98 to -2.10, p= 0.06). Preoperative TXA did not significantly reduce intraoperative bleeding. Future RCTs should assess surgical techniques, TXA dosage, bleeding measurement, patient age, and postoperative medications.
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