Evidence map›Paper›PMID 41127669›Full record

ArticleFrontiers in cellular and infection microbiology2025

M2-type macrophage nanovesicles regulate the inflammatory response after necrotizing enterocolitis by inducing M1 to M2-like macrophage polarization.

Chang Liu, Jie Gong, Lin Zhang, Yu Wang, YaJun Huang, Rong Ju

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chang Liu *Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Jie Gong *Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Lin Zhang *Department of Neonatology, People's Hospital of Jianyang City, Jianyang, China.
Yu WangChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
YaJun HuangDepartment of Neonatology, The Affiliated Chengdu 363 Hospital of Southwest Medical University, Chengdu, China.
Rong JuChengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is a serious inflammatory gastrointestinal disorder leading to a devastating intestinal inflammatory response, which typically results in severe sepsis and death. Given the imbalance of inflammatory response in the intestine that results in immune dysregulation and further worsens the clinical symptoms of NEC. Macrophages are the primary cells responsible for the early regulation and resolution of intestinal inflammation, therefore our experiments focus on the regulation of the polarization type of macrophages. In this study, we applied a convenient and continuous extrusion system to execute and purify M2NVs from RAW264.7 macrophage cells, then used to interfere with the LPS-induced cell inflammation model and NEC animal model. We discovered that M2NVs could foster the polarization of M1 to M2 macrophages and inhibit inflammatory injury

Indexed as

Enterocolitis, NecrotizingInflammationMacrophage ActivationMacrophagesAnimalsCytokinesDisease Models, AnimalLipopolysaccharidesMiceMice, Inbred C57BLRAW 264.7 CellsCytokinesLipopolysaccharidesgastrointestinal disorderinflammatory responsemacrophages polarizationnanovesiclenecrotizing enterocolitispolarization

Identifiers

PMID41127669
PMCPMC12537678

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.