Evidence map›Paper›PMID 41127637›Full record

ArticleACS catalysis2025

Unspecific Peroxygenases for the Enzymatic Removal of Alkyl Protecting Groups in Organic Synthesis.

Lina A Csechala, Maximilian Wutscher, Verena Scheibelreiter, Stefan Giparakis, Ina Menyes, Thomas Bayer, Christian Stanetty, Florian Rudroff, Uwe T Bornscheuer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Empowering Precision C-H Functionalization: Advances in Peroxygenase Engineering.Angewandte Chemie (International ed. in English) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lina A CsechalaDepartment of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Felix-Hausdorff-Str. 4, Greifswald 17489, Germany.ORCID https://orcid.org/0009-0004-8037-6469
Maximilian WutscherInstitute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9, Vienna 1060, Austria.ORCID https://orcid.org/0009-0006-5200-2018
Verena ScheibelreiterInstitute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9, Vienna 1060, Austria.ORCID https://orcid.org/0000-0002-8236-9658
Stefan GiparakisInstitute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9, Vienna 1060, Austria.
Ina MenyesDepartment of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Felix-Hausdorff-Str. 4, Greifswald 17489, Germany.
Thomas BayerDepartment of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Felix-Hausdorff-Str. 4, Greifswald 17489, Germany.ORCID https://orcid.org/0000-0002-0656-3280
Christian StanettyInstitute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9, Vienna 1060, Austria.ORCID https://orcid.org/0000-0001-7692-6932
Florian RudroffInstitute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9, Vienna 1060, Austria.ORCID https://orcid.org/0000-0002-6680-8200
Uwe T BornscheuerDepartment of Biotechnology & Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Felix-Hausdorff-Str. 4, Greifswald 17489, Germany.ORCID https://orcid.org/0000-0003-0685-2696

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective protection and deprotection of hydroxyl groups is pivotal in multistep organic synthesis to circumvent undesired side reactions. Alkyl ethers are highly stable and atom-economic protecting groups (PGs), but demand harsh and hazardous conditions for removal, limiting their utility. Consequently, there is a high demand for biocatalysts as milder, selective, and scalable alternatives, which can be met by a class of heme-thiolate enzymes: unspecific peroxygenases (UPOs). Herein, we report the identification of UPO23 in a commercial enzyme panel as a robust biocatalyst for

Indexed as

biocatalysisether cleavageO-dealkylationprotection group chemistryunspecific peroxygenases

Identifiers

PMID41127637
PMCPMC12538550

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.