ArticleFrontiers in microbiology2025
Rotavirus A genotype diversity and antigenic profile in Central Ethiopia: implications for rotarix
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Hidden Circulation and Socio-Sanitary Vulnerability: Rotavirus A and Human Adenovirus Prevalence in Symptomatic and Asymptomatic Children in Central Brazil Post-COVID-19.Pathogens (Basel, Switzerland) · 2025Article
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Abstract
Introduction: Rotavirus remains a leading cause of severe gastroenteritis in children globally, including in Ethiopia. Despite the introduction of vaccines, high mutation and reassortment rates contribute to genetic diversity and potential vaccine escape. This study aimed to assess the distribution and genetic characteristics of rotavirus A (RVA) strains in children under five with diarrhea in central Ethiopia, with comparison to the Rotarix Methods: Stool samples were collected from children under 5 years of age presenting with diarrhea at health centers in Debre Berhan and Addis Ababa between April 2022 and December 2023. RVA was detected using quantitative real-time PCR (qPCR). Genotyping was performed by Sanger sequencing of the VP7 and VP4 genes. Phylogenetic analysis was performed in MEGA X software using the maximum likelihood method with 1,000 bootstrap replicates, using reference sequences retrieved from the GenBank database. Amino acid sequences of these proteins were compared with those of the Rotarix Results: RVA was detected in 30 of 247 samples (12.14%), with 28 successfully genotyped. G9 was the predominant G genotype (50%), followed by G12 (10.2%), G2 (7.1%), G1 (3.6%), and G3 (3.6%); 25% remained untyped. P[4] was the most common P genotype (28.6%), followed by P[6] (21.4%) and P[8] (17.9%), with 32.1% untyped. The most frequent G/P combinations were G9P[4] (35%), G12P[6] (13%), and G9P[8] (9%). Compared to Rotarix Conclusion: The dominance of the G9P[4] genotype, together with substantial amino acid substitutions in the current circulating RVA strains that diverge from the G1P[8] Rotarix
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