ArticleMaterials today. Bio2025
Multimodal antibacterial microneedles with nanozymes mediated ROS-scavenging and oxygen-generation synergistic photothermal/photodynamic therapy to promote diabetic ulcer healing.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Gas-propelled microneedles for precision transdermal therapeutics.Bioactive materials · 2027Review
- NIR-Assisted Multimodal Strategies for Enhanced Antibacterial Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- [Evolution of DFU treatment strategies: from simple coverage with traditional dressings to active modulation with smart materials].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Metal organic framework based synergistic improvement of hypoxia for optimizing diabetic wounds healing.Materials today. Bio · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of diabetic ulcers often becomes complicated because of complex microenvironmental factors such as infection, oxidative stress, and hypoxia. To address these issues, we developed a multifunctional microneedle system IR780-Ce-MOF@MN (ICMN) integrated with nanozymes for synergistic therapy. This system combines photothermal (PTT) and photodynamic (PDT) therapies with metal-organic framework (MOF) based catalysis to enable broad-spectrum antibacterial activity, regulate redox homeostasis, and alleviate hypoxia, collectively accelerating wound healing. The ICMN operates through an auto-circulating "antibacterial, antioxidant, oxygen supplying" mechanism. It physically disrupts biofilms with an efficiency of 80.65 ± 1.29 % and releases nanozymes composed of IR780 and Ce-MOFs, which exhibit potent antibacterial effects against
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Registered trials
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