Evidence map›Paper›PMID 41127533›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

Iron deficiency anemia is associated with depressive symptoms in adolescents with heavy menstrual bleeding.

Ramya Ramakrishnan, Hansa Boddu, Kaleigh Riggs-Harpur, Lakshmi V Srivaths, Asha Davidson, Rebecca M Beyda, Neethu M Menon

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Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Ramya RamakrishnanDepartment of Pediatrics, The University of Texas Health Science Center at Houston, MD Anderson Cancer Center, Houston, , Texas, USA.
Hansa BodduMcGovern Medical School, The University of Texas Health Science Center at Houston, Texas, USA.
Kaleigh Riggs-HarpurPediatric Research Center, Department of Pediatrics McGovern Medical School, The University of Texas Health Science Center at Houston, Texas, USA.
Lakshmi V SrivathsDepartment of Pediatrics, Division of Hematology and Gulf States Hemophilia Thrombophilia Center, Texas, USA.
Asha DavidsonDivision of Adolescent Medicine, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Texas, USA.
Rebecca M BeydaDivision of Adolescent Medicine, Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Texas, USA.
Neethu M MenonDepartment of Pediatrics, Division of Hematology and Gulf States Hemophilia Thrombophilia Center, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Heavy menstrual bleeding (HMB) and associated iron deficiency (ID) with anemia (IDA) or without anemia lead to adverse health outcomes for adolescents. Objectives: This descriptive study aimed to assess the association between ID/IDA and depressive symptoms, as measured by Patient Health Questionnaire (PHQ)-9 scores, among adolescents with HMB. Methods: This is a single-center retrospective records review of adolescents with physician-documented HMB and at least 1 PHQ-9 score, evaluated in a specialty clinic. With ID defined as ferritin of <25 ng/dL and IDA as hemoglobin (Hgb) of <12 g/dL, univariate and multivariate statistical models were used to compare ID/IDA with PHQ-9 scores cross-sectionally and longitudinally. We hypothesized that the incidence of PHQ-9 scores of ≥10 would be higher among patients with ID/IDA than that in those without. Results: Among 123 adolescents with HMB, 90 had ID and 61 had IDA; 37% of those with ID (33/90) and 51% of those with IDA (31/61) had a PHQ-9 score of ≥10 at baseline ( Conclusion: This study highlights the importance of addressing and optimally managing depressive symptoms in adolescents with HMB and related IDA.

Indexed as

antifibrinolytic therapybleeding disorderethnicityferritinhemoglobinhormonal therapyintravenous ironiron deficiencyobesityoral ironPatient Health Questionnaire (PHQ-9)pictorial blood assessment chart

Identifiers

PMID41127533
PMCPMC12539287

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.