Evidence map›Paper›PMID 41127529›Full record

ArticleRSC chemical biology2025

Chemically inducible antisense oligonucleotides for cell-specific gene silencing.

Zhen Xun, Yang Hai, Li-Juan Tang, Jian-Hui Jiang, Zhenkun Wu

Abstract read
In one paragraph

Article in RSC chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhen XunState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University Changsha 410082 China tomwu@hnu.edu.cn.
Yang HaiState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University Changsha 410082 China tomwu@hnu.edu.cn.ORCID https://orcid.org/0000-0002-6130-2841
Li-Juan TangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University Changsha 410082 China tomwu@hnu.edu.cn.
Jian-Hui JiangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University Changsha 410082 China tomwu@hnu.edu.cn.ORCID https://orcid.org/0000-0003-1594-4023
Zhenkun WuState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University Changsha 410082 China tomwu@hnu.edu.cn.ORCID https://orcid.org/0000-0001-6458-5659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-specific control of the function of antisense oligonucleotides (ASOs) is highly desirable for precise gene therapy while minimizing adverse effects in normal cells. Herein, we report a novel class of chemically inducible ASOs (iASOs) that achieve tumor-cell-selective gene silencing through hydrogen peroxide (H

Identifiers

PMID41127529
PMCPMC12538225

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.