Trial reportDrug design, development and therapy2025
Effects of Dexmedetomidine Nasal Sprays on Postoperative Sleep Quality in Patients Who Underwent Laparoscopic Gynaecological Surgery: A Single-Centre, Double-Blind, Randomized Controlled Study.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of intranasal dexmedetomidine on postoperative sleep quality: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Effect of Dexmedetomidine Hydrochloride Nasal Spray on Anxiety and Sleep in Patients Undergoing Gynecological Laparoscopic Surgery.Medical science monitor : international medical journal of experimental and clinical research · 2026Trial
- Effects of dexmedetomidine nasal spray on perioperative anxiety and quality of postoperative recovery in patients undergoing modified radical mastectomy for breast cancer.Frontiers in medicine · 2026Trial
- Effects of Perioperative Intranasal Dexmedetomidine Spray on Clinical Outcomes of Pulsed Radiofrequency in Patients with Zoster-Associated Pain: A Randomized Controlled Trial.Journal of pain research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dexmedetomidine nasal sprays is effective for perioperative sedation, analgesia, and anxiolysis. Nevertheless, its impact on postoperative sleep quality along with the optimal dosage and overall efficacy remains unclear in patients undergoing laparoscopic gynecological surgery. Methods: A total of 150 adult patients undergoing laparoscopic gynecological surgery were enrolled, with 144 included in the final analysis. Patients in the dexmedetomidine (Dex) group received 50 µg of intranasal dexmedetomidine 30 minutes before sleep on the first postoperative night, while the control group received an equivalent volume of saline. Primary outcomes included objective sleep parameters (sleep duration, deep sleep duration, REM sleep duration and light sleep duration) measured via a portable sleep monitor, as well as subjective sleep parameters assessed by Athens Insomnia Scale (AIS) and Numerical Rating Scale (NRS) scores one night before and on the first night after surgery. Secondary outcomes comprised postoperative pain measured by VAS, nausea and vomiting, and average heart rate. Results: The sleep duration, deep sleep duration and REM sleep duration of patients in the control group decreased after laparoscopic gynaecological surgery (vs preoperative control group, Conclusion: Dexmedetomidine nasal sprays improved postoperative sleep quality in patients who underwent laparoscopic gynaecological surgery. Trial Registration: Chinese Clinical Trial Registry (clinical trial number: ChiCTR2400080181).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.