Trial reportDrug design, development and therapy2025
Oxycodone versus Sufentanil for Postoperative Recovery in Obese Patients Undergoing Laparoscopic Bariatric Surgery: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07753785 (Effects of Oliceridine Versus Sufentanil Analgesia on Incidence of Postoperative Respiratory Depression in Patients at High-Risk of Obstructive Sleep Apnea), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Oliceridine Versus Sufentanil Analgesia on Incidence of Postoperative Respiratory Depression in Patients at High-Risk of Obstructive Sleep Apnea: A Prospective Cohort Study
Who cites it
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Authors and funding
8 authors.
Funding
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Abstract
Purpose: Obese patients undergoing bariatric surgery face unique challenges in postoperative pain management and recovery. Due to altered opioid pharmacokinetics and heightened pain sensitivity in this population, optimizing analgesic regimens is crucial. This study compared the impact of oxycodone- vs sufentanil-based analgesic regimens on postoperative recovery quality in obese patients undergoing bariatric surgery. Methods: Eighty-four obese patients (BMI ≥30 kg/m², ASA II-III) undergoing elective laparoscopic bariatric surgery were randomized into oxycodone (n=42) or sufentanil (n=42) groups. Standardized anesthesia included either oxycodone (0.3 mg/kg at induction, 0.1 mg/kg 10 min before surgery completion) or sufentanil (0.3 µg/kg at induction, 0.1 µg/kg 10 min before surgery completion). The primary outcome was the Quality of Recovery-40 (QoR-40) score at 24 h postoperatively. Secondary outcomes included NRS pain scores, rescue analgesia requirements, adverse events (PONV and hypoxemia), sedation scores, and recovery milestones. Results: Compared to the sufentanil group, the oxycodone group had significantly higher 24-hour QoR-40 scores (median [IQR]: 187.0 [178.8-190.3] vs 173.0 [164.8-184.3]; estimated median difference: 11; 95% CI: 6-17; Conclusion: Oxycodone significantly enhanced postoperative recovery quality compared with sufentanil in obese patients undergoing laparoscopic bariatric surgery, providing superior analgesia and reducing opioid-related side effects.
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