Evidence map›Paper›PMID 41127362›Full record

Trial reportDrug design, development and therapy2025

Ciprofol vs Propofol for Intraoperative Neurophysiological Monitoring in Elderly Patients Undergoing Spinal Surgery: A Randomized Controlled Trial.

Gaofeng Fan, Zhenzhen Hu, Suyue Zheng, Shibiao Chen, Kun Yi, Shiping Yin, Wenjie Sun

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gaofeng Fan *Department of Anesthesiology, the First Affiliated Hospital, Jiangxi Medica College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Zhenzhen Hu *Department of Anesthesiology, the First Affiliated Hospital, Jiangxi Medica College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Suyue Zheng *Department of Neurosurgery, the First Affiliated Hospital, Jiangxi Medica College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Shibiao ChenDepartment of Anesthesiology, the First Affiliated Hospital, Jiangxi Medica College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Kun YiDepartment of Anesthesiology, the First Affiliated Hospital, Jiangxi Medica College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.ORCID 0009-0008-1470-5550
Shiping YinDepartment of Anesthesiology, the First Affiliated Hospital, Jiangxi Medica College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Wenjie SunDepartment of Anesthesiology, the First Affiliated Hospital, Jiangxi Medica College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.ORCID 0009-0005-2797-8572

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to compare the effects of ciprofol and propofol on motor evoked potentials (MEPs) and somatosensory evoked potentials (SEPs) in elderly patients undergoing spinal surgery. Patients and Methods: This trial enrolled 60 elderly patients scheduled for elective spinal surgery with intraoperative neurophysiological monitoring (IONM) and assigned them to Group C (receiving ciprofol) or Group P (receiving propofol) using random allocation. Primary outcome measures focused on MEPs and SEPs amplitudes of lower extremities at T6. The secondary outcomes encompassed neurophysiological measures (MEPs and SEPs latencies at T6, as well as their amplitudes and latencies at T5), hemodynamic parameters of heart rate (HR), mean arterial pressure (MAP), and bispectral index (BIS) values at T1-T6, along with the incidence of hypotension, bradycardia, requirements for vasoactive medications. Results: Neurophysiological recordings at T6 showed significantly higher amplitudes in Group C across all measured parameters during inter-group comparison. For MEPs, Group C demonstrated greater amplitudes in lower extremities (1378 μV, IQR 1256-1605 vs 1121 μV, IQR 1077-1307; Conclusion: Ciprofol outperforms propofol in hemodynamic stability for the elderly undergoing spinal surgery, with less suppression of the amplitudes of MEPs and SEPs, and no prolongation of latency, thereby potentially improving the quality of IONM. Trial Registration Clinicaltrialsgov Identifier: ChiCTR2400091429.

Indexed as

Intraoperative Neurophysiological MonitoringPropofolSpineAgedAged, 80 and overAnesthetics, IntravenousCyclopropanesEvoked Potentials, MotorEvoked Potentials, SomatosensoryFemaleHumansMale(2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenolAnesthetics, IntravenousCyclopropanesPropofolciprofolelderly patientsneurophysiologic monitoringpropofolspinal surgery

Identifiers

PMID41127362
PMCPMC12537811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.