Evidence map›Paper›PMID 41127334›Full record

ArticleMolecular therapy. Nucleic acids2025

Cell-penetrating antibody enhances nuclear delivery of triplex-forming oligonucleotides targeting HER2-positive cancers.

Anthony Minnah, Nicole M García Tubéns, Adam Krysztofiak, Yanfeng Liu, Peter M Glazer, Faye A Rogers

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anthony MinnahDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06510, USA.
Nicole M García TubénsDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06510, USA.
Adam KrysztofiakDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06510, USA.
Yanfeng LiuDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06510, USA.
Peter M GlazerDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06510, USA.
Faye A RogersDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06510, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleic acid therapies (NATs) such as triplex-forming oligonucleotides (TFOs) offer innovative cancer treatment options to selectively target amplified oncogenes, such as

Indexed as

antibody-DNA conjugatesHER2-positive breast cancerMT: Delivery Strategiesnucleic acid delivery strategiestriplex-forming oligonucleotidestumor delivery

Identifiers

PMID41127334
PMCPMC12538099

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.