ArticleFrontiers in chemistry2025
The detection of serum-volatile organic compounds in the diagnostics of hepatocellular carcinoma using gas chromatography-ion mobility spectrometry.
Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Electronic nose versus gas chromatography - mass spectrometry for diagnostic discrimination of advanced hepatocellular carcinoma by volatolomic analysis.BMC gastroenterology · 2026Article
- GC-IMS-based analysis of serum volatile organic compounds for diagnosis of gastric cancer.Scientific reports · 2026Article
- Volatile organic compound profiling by HS-GC-IMS for vaginal infection identification.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
6 authors.
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Abstract
Introduction: The third most common cause of cancer-related death worldwide is hepatocellular carcinoma (HCC), a malignant liver tumor that usually arises in patients with cirrhosis and chronic liver disease. New biomarkers are required for bidirectional validation of HCC in clinical practice because of its early asymptomatic stage, high mortality rate, and rapid tumor growth, as well as the high rate of false-positive results obtained for the commonly used serum marker alpha-fetoprotein (AFP). Methods: This study used gas chromatography-ion mobility spectrometry (GC-IMS) combined with chemometrics to analyze the differences in volatile organic compounds (VOCs) in the serum of patients with and without hepatocellular carcinoma (HCC) in order to explore new biomarkers of HCC. Results: The GC-IMS analysis detected 31 VOCs in serum, including 8 ketones, 11 aldehydes, 6 alcohols, 2 esters, and 1 furans, many of which differed in content between the controls and the patients with HCC. Conclusions: The VOCs obtained from the use of these analytical devices can serve as a reference for developing low-cost equipment in the future. Considering its high efficiency and low cost, the detection of volatile organic compounds can be used as an auxiliary means of diagnosis or for mass screening of the population.
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