SynthesisFrontiers in aging neuroscience2025
Cognitive changes preceding Parkinson's disease: a systematic review and meta-analysis of prospective population-based studies.
Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive correlates of decision-making in Parkinson's disease: a systematic review.Frontiers in aging neuroscience · 2026Pooled it
- Financial abilities in patients with Parkinson's disease and mild cognitive impairment: unveiling cognitive and neurofunctional correlates of basic and advanced financial skills.Frontiers in aging neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Various non-motor symptoms have been studied as part of the prodromal phase of Parkinson's disease (PD). However, studies assessing cognitive changes are scarce. Methods: We systematically searched PubMed and SCOPUS to identify prospective, population-based studies that reported on cognitive performance in individuals without PD at baseline, the incidence of PD at follow-up, and comparisons of cognitive performance between participants who developed PD and controls. Results: Twelve studies were identified, including a total of 524,807 participants, of whom 2,939 developed PD. Four studies found differences in global cognition and a meta-analysis showed that individuals who developed PD scored 0.3 points lower than controls on the Mini-Mental State Examination at baseline. Cognitive changes were most frequently observed in tests of executive function, processing-speed and attention, and less frequently in visuospatial/visuoconstructive skills and memory. Due to the heterogeneity of the assessment methods used, it was not possible to conduct further meta-analyses. Conclusions: Cognitive changes may be part of the clinical picture in prodromal PD cohorts derived from the general population. Further population-based studies with large samples and long-term follow-up are needed to better understand their extent and significance. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024547252, identifier: CRD42024547252.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.