Evidence map›Paper›PMID 41127147›Full record

ArticleInfection and drug resistance2025

What are the Real-Life Dilemmas and Facilitators of Medication Adherence of Patients with Drug-Resistant Tuberculosis: A Qualitative Exploration of Patient Perspectives.

Xiaoli Xia, Fuli Huang, Ying Wang, Xue Lin, Jie Cheng, Tingting Chen, Liwen Jiang, Yanhua Chen, Daiying Zhang, Jian Tang

Abstract read
In one paragraph

Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The "yeast-drop" treatment protocol in theFrontiers in tuberculosis · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoli XiaSchool of Nursing, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Fuli HuangDepartment of Infectious Diseases, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Ying WangDepartment of Infectious Diseases, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Xue LinSchool of Nursing, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.ORCID 0009-0004-8703-0559
Jie ChengSchool of Nursing, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Tingting ChenSchool of Nursing, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Liwen JiangSchool of Nursing, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Yanhua ChenSchool of Nursing, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Daiying ZhangDepartment of Operating Room, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Jian TangDepartment of Infectious Diseases, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.ORCID 0000-0003-2262-9419

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Drug-resistant tuberculosis (DR-TB) constitutes a global public health crisis, which endangers patients' health, poses a significant transmission risk, and imposes a substantial strain on the healthcare system. Medication adherence is essential for enhancing treatment outcomes and mitigating the proliferation of DR-TB. Purpose: This study aims to explore the real-life dilemmas and facilitators affecting medication adherence in DR-TB patients and provide a reference for improving medication compliance in DR-TB patients. Patients and Methods: A descriptive qualitative study was conducted. 26 patients with DR-TB who were treated with oral medication regimen in a tertiary hospital in Luzhou City, Sichuan Province from March to May 2025 were selected through purposive sampling method for semi-structured interviews, and thematic analysis was used to analyze the data. Results: Five themes and fourteen sub-themes affecting medication adherence of DR-TB patients were identified, encompassing: Individual physiological traits (age-related variations in the perception of future time, polypharmacy in patients with comorbidities), intricate psychology and behaviors (misconceptions of medication effects, psychological distress resulting from stigma, misunderstanding of disease conditions, downward social comparison, divergences in medicine administration practices), synergy in social networks (multi-dimensional support of family members, support and communication from health providers), differences in family finances and living situations (significant family financial strain, influence of family roles), and constraints on medical insurance services (disparities in health insurance coverage, intricacy of the reimbursement procedure, constraints on reimbursement amounts and coverage). Conclusion: Adherence to medication among DR-TB patients is influenced by intricate factors. Health professionals should intervene on the basis of a comprehensive and dynamic assessment of medication adherence to address these influencing factors at various levels, thereby enhancing adherence and therapeutic outcomes.

Indexed as

drug-resistant tuberculosishealth ecology modelinfluencing factorsmedication adherencequalitative research

Identifiers

PMID41127147
PMCPMC12537523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.