Evidence map›Paper›PMID 41127143›Full record

ArticleGastro hep advances2026

Swallowed Nasal Fluticasone Spray for Eosinophilic Esophagitis: An Affordable and Off-Label Path to Histologic Remission.

Jameel Alp, Alyssa M Bren, Tyson Sievers, Joshua A Sloan

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PubMed Full text at PMC Publisher
In one paragraph

Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jameel AlpDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota.
Alyssa M BrenJohn T. Milliken Department of Medicine, Washington University, St. Louis, Missouri.
Tyson SieversMinnesota Gastroenterology Digestive Health, Minneapolis, Minnesota.
Joshua A SloanDivision of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Swallowed topical corticosteroids are among the first-line therapies for eosinophilic esophagitis, with budesonide oral suspension recently approved by the Food and Drug Administration. However, off-label options such as fluticasone from metered-dose inhalers remain widely used due to cost and access barriers. We report a case of histologic remission achieved using over-the-counter fluticasone nasal spray administered orally with honey-an approach not previously described in the literature. This patient-led, low-cost method followed incomplete response to both proton pump inhibitors and fluticasone metered-dose inhaler. The case may illustrate a potential alternative steroid delivery method in eosinophilic esophagitis for resource-conscious, individualized care.

Indexed as

Cost-effective treatmentEosinophilic esophagitisFluticasone nasal sprayHistologic remissionPatient-centered care

Identifiers

PMID41127143
PMCPMC12538440

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.