ArticleFrontiers in nutrition2025
Major adverse kidney events among chronic kidney disease patients with vitamin D deficiency.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Vitamin D deficiency, multimorbidity, and mortality in stage 2 cardiovascular-kidney-metabolic (CKM) Syndrome: evidence from the NHANES 2001-2018 cohort.Renal failure · 2026Article
- Preoperative GLP-1 Receptor Agonist (GLP-1 RA) Exposure Is Associated With Postoperative Initiation of GLP-1 RA Following Metabolic Bariatric Surgery: A Multicenter Cohort Study.Obesity surgery · 2026Article
- Serum 25(OH)D concentration and risk of all-cause and cause-specific mortality in patients with chronic kidney disease: systematic review and dose-response meta-analysis of observational cohort studies.Nutrition & metabolism · 2026Review
- Vitamin D and Vitamin D Analogues in Hemodialysis Patients: A Review of the Literature.International journal of molecular sciences · 2025Review
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Authors and funding
8 authors.
Funding
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Abstract
Objective: This study aimed to evaluate the association of vitamin D deficiency (VDD) and major adverse kidney events (MAKEs) among patients with chronic kidney disease (CKD). Methods: We conducted a retrospective cohort study using the TriNetX Global Collaborative Network. Eligible participants were adults with CKD who had a vitamin D testing between January 01, 2010 and January 31, 2025. According to the status of vitamin level, individuals were classified into two groups, VDD group and control group. Propensity score matching (PSM) was applied to balance baseline characteristics between groups. The primary outcome was the risk of MAKEs during one-year follow-up, while secondary outcomes included all-cause mortality and all-cause hospitalization. Results: After PSM, 29,654 patients were included in each group. The VDD group was associated with a higher risk of MAKEs (hazard ratio [HR], 2.24; 95% confidence interval [CI], 2.08-2.41; Conclusion: VDD in patients with CKD is associated with a significantly higher risk of MAKEs. The finding suggests that VDD may contribute to worse adverse kidney events and highlight the importance of vitamin D status in the clinical management.
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