ArticleFrontiers in pharmacology2025
3-Hydroxytyrosol as a phenolic cholinesterase inhibitor with antiamnesic activity: a multimethodological study of selected plant phenolics.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Review
- Gallic Acid, 3-Hydroxytyrosol, and Quercetin Modulate Cholinesterase Activity inInternational journal of molecular sciences · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
Background: Plant phenolics are increasingly being investigated for their diverse biological activities, including neuroprotective effects relevant to conditions like Alzheimer's disease. Objective: The neurobiological potential of 37 plant phenolics was screened through a multifaceted approach encompassing Methods: The compounds were tested for their cholinesterase (ChE) inhibition potentials, metal-chelation activities, and copper-reducing antioxidant capacities (CUPRACs) using a microtiter assay as well as ferric-reducing antioxidant power assays. Additionally, the Results: Several compounds exhibited significant inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Of these, quercetin was found to be the most active inhibitor, with IC Conclusion: Our data provide compelling evidence for the neuroprotective potentials of several plant phenolics. Notably, 3-hydroxytyrosol was identified for the first time as a ChE inhibitor with significant
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