ArticleiScience2025
Liver microbial DNA signatures and extracellular vesicle epitopes as predictors of post-hepatectomy liver failure.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Role of Gut Microbiota in Liver Regeneration After Partial Hepatectomy: New Evidence From Animal and Human Studies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions between the livers cellular environment and intestinal microbiota are involved in liver disease progression and health. This study investigates the impact of intra-hepatic microbial particles on liver regeneration (LR) following 70% partial hepatectomy (PH). We focus on the gut-liver axis and the relationship between gut and liver bacterial profiles. The study highlights microbial DNA and extracellular vesicles in liver tissue, examines bacterial translocation, microbiota manipulation, dysbiosis, and microbiome diversity, and assesses the impact of bacterial factors such as motility, spore formation, aerobic nature, and short-chain fatty acid (SCFA) production on LR capacity. We found that bacterial DNA and extracellular vesicles translocate to the liver post-surgery. While gut and liver bacterial profiles differ, some consistency remains. A dysbiotic gut microbiome leads to a dysbiotic liver profile, negatively impacting survival, and LR. Positive correlations with LR were observed for non-acetate and butyrate producers, spore-forming, and non-motile bacteria, whereas Gram-positive bacteria correlated negatively.
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Registered trials
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