ReviewAmerican heart journal plus : cardiology research and practice2025
Gut microbiome dysbiosis in heart failure: Updated evidence, mechanisms, and therapeutic directions.
Review in American heart journal plus : cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Gut microecology and cardiovascular disease: core pathogenic mechanisms and clinical intervention strategies.Folia microbiologica · 2026Review
- Progressive Shifts in Oral Plaque Microbiota From Health to Coronary Artery Disease and Acute Myocardial Infarction.Cardiology research · 2026Article
- The Gut Microbiome in Heart Failure: Pathways to Inflammation and Therapeutic Targets.Metabolites · 2026Review
- Functional Capacity and Gut Microbiota Shifts in Heart Failure Patients Following Cardiac Rehabilitation.Journal of clinical medicine · 2026Article
- Targeting the Gut-Heart Axis in Diabetic Heart Failure: Microbiota and SGLT2is as Converging Therapeutic Frontiers.International journal of molecular sciences · 2026Review
- The essential role of hydrogen gas recycling by gut microbes in reducing deuterium load in host mitochondria: is trimethylamine oxide a deuterium sensor?Metabolomics : Official journal of the Metabolomic Society · 2026Review
- Letter to the editor: data accuracy.American heart journal plus : cardiology research and practice · 2026Article
- Gut Microbiota-Derived Trimethylamine N-Oxide and NT-proBNP in Heart Failure: A Critical Review of Diagnostic and Prognostic Value.Biomedicines · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Emerging evidence suggests a significant link between the gut microbiome and cardiovascular health, yet its role in the pathophysiology of heart failure has been underexplored. This systematic review and meta-analysis synthesize available research on how gut microbiota influence heart failure, offering new insights into therapeutic interventions. Methods: We conducted a comprehensive search of multiple databases for studies published up to the present, focusing on observational and experimental research that examines the relationship between the gut microbiome and heart failure outcomes. Eligibility criteria included studies on humans with diagnosed heart failure, assessments of microbiome composition, and reported cardiovascular outcomes. Quality assessment was performed using standardized tools, and meta-analysis was conducted to quantify the impact of microbiome diversity and composition on heart failure progression and response to treatment. Results: The analysis included 25 studies encompassing 3200 patients with heart failure. Specific microbial profiles, particularly an increased abundance of Conclusions: This review highlights the gut microbiome as a potential target for innovative therapeutic strategies in heart failure management. Modulating gut microbiota composition and diversity through dietary interventions, probiotics, or microbiome transplantation could offer new avenues for improving cardiovascular outcomes in heart failure patients. Integrative approaches in cardiovascular healthcare should consider the gut-heart axis for comprehensive disease management.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.