Evidence map›Paper›PMID 41126870›Full record

ArticleAmerican heart journal plus : cardiology research and practice2025

Circulating prothymosin alpha and immunoglobulin G3 in acute rheumatic fever and rheumatic heart disease: A case-control study.

Gul Afshan, Nicole Tsui, Humera Javed, Tehmina Kazmi, Emma Ndagire, Jafes Pulle, Kristin Huse, Amelia Lias, Shagorika Talukder, Natalie Lorenz and 7 more

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Article in American heart journal plus : cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Valve biology and rheumatic heart disease pathogenesis.Nature cardiovascular research · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Gul AfshanUniversity of Child Health Sciences, Children's Hospital Lahore, Lahore, Pakistan.
Nicole TsuiImperial College London, London, UK.
Humera JavedUniversity of Child Health Sciences, Children's Hospital Lahore, Lahore, Pakistan.
Tehmina KazmiUniversity of Child Health Sciences, Children's Hospital Lahore, Lahore, Pakistan.
Emma NdagireUganda Heart Institute, Kampala, Uganda.
Jafes PulleUganda Heart Institute, Kampala, Uganda.
Kristin HuseImperial College London, London, UK.
Amelia LiasImperial College London, London, UK.
Shagorika TalukderImperial College London, London, UK.
Natalie LorenzUniversity of Auckland, Auckland, New Zealand.
Reuben McGregorUniversity of Auckland, Auckland, New Zealand.
Craig SableOchsner Children's Hospital, New Orleans, LA, USA.
Andrea Z BeatonCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Nicole J MorelandUniversity of Auckland, Auckland, New Zealand.
Emmy OkelloUganda Heart Institute, Kampala, Uganda.
Masood SadiqUniversity of Child Health Sciences, Children's Hospital Lahore, Lahore, Pakistan.
Tom ParksImperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The lack of specific diagnostic tests for acute rheumatic fever (ARF) and its consequence rheumatic heart disease (RHD) is a key barrier to effective control of these diseases in low resource settings. Methods: We used immunoassays to evaluate blood prothymosin alpha (PTA) and immunoglobulin G3 (IgG3) in patients with ARF, RHD and controls using serum samples from Pakistan and plasma samples from Uganda. Results: Across both sets of samples, we found total IgG3 was significantly elevated in definite ARF ( Discussion: Our findings conflict with a previous report that found PTA was elevated in RHD compared to healthy controls. In contrast, while less marked than before, we found IgG3 was elevated in ARF, extending this observation to settings where the impact of RHD is greatest.

Indexed as

Acute rheumatic feverBiomarkersImmunoglobulin-G3Prothymosin-alphaRheumatic heart diseaseStreptococcus pyogenes

Identifiers

PMID41126870
PMCPMC12537566

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.