Evidence map›Paper›PMID 41126839›Full record

ArticleFrontiers in immunology2025

Dynamics of NK cell subsets following autologous hematopoietic stem cell transplantation in adult oncologic patients.

Gabirel Astarloa-Pando, Victor Sandá, Ainhoa Amarilla-Irusta, Ainara Lopez-Pardo, Itxaso San Juan, Ainhoa Iturbe-Larrondo, Raquel Pérez-Garay, Silvia Pérez-Fernández, Borja Santos-Zorrozúa, Bárbara Manzanares-Martín and 11 more

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Gabirel Astarloa-PandoImmunopathology Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Victor SandáImmunopathology Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Ainhoa Amarilla-IrustaImmunopathology Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Ainara Lopez-PardoImmunopathology Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Itxaso San JuanImmunopathology Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Ainhoa Iturbe-LarrondoImmunopathology Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Raquel Pérez-GarayImmunopathology Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Silvia Pérez-FernándezScientific Coordination Facility, Biobizkaia Health Research Institute, Barakaldo, Spain.
Borja Santos-ZorrozúaScientific Coordination Facility, Biobizkaia Health Research Institute, Barakaldo, Spain.
Bárbara Manzanares-MartínClinical Management Unit of Immunology and Allergy, Reina Sofia Hospital, Córdoba, Spain.
Raquel BernardoClinical Management Unit of Immunology and Allergy, Reina Sofia Hospital, Córdoba, Spain.
Carmen GonzálezBiogipuzkoa Health Research Institute, Hematology and Hemotherapy Service, Donostia University Hospital, Donostia-San Sebastián, Spain.
Alasne UrangaBiogipuzkoa Health Research Institute, Hematology and Hemotherapy Service, Donostia University Hospital, Donostia-San Sebastián, Spain.
Mercedes ReyBiogipuzkoa Health Research Institute, Service of Immunology, Donostia University Hospital, Donostia-San Sebastián, Spain.
Marta AlonsoRegulation of the Immune System Group, Biobizkaia Health Research Institute, Immunology Service, Cruces University Hospital, Barakaldo, Spain.
Elena AmutioHematological Cancer Group, Biobizkaia Health Research Institute, Hematology and Hemotherapy Service, Cruces University Hospital, Barakaldo, Spain.
Juan J Mateos-MazónHematological Cancer Group, Biobizkaia Health Research Institute, Hematology and Hemotherapy Service, Cruces University Hospital, Barakaldo, Spain.
Juan C García-RuizHematological Cancer Group, Biobizkaia Health Research Institute, Hematology and Hemotherapy Service, Cruces University Hospital, Barakaldo, Spain.
Olatz ZenarruzabeitiaImmunopathology Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Laura AmoImmunopathology Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Francisco BorregoImmunopathology Group, Biobizkaia Health Research Institute, Barakaldo, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early immune reconstitution following autologous hematopoietic stem cell transplantation (autoHSCT) is associated with improved outcome in various cancers. Natural killer (NK) cells are the first lymphocyte subset to recover post-autoHSCT and play a crucial role in antitumor immunity. In this study, we have performed an in-depth characterization of NK cells in adult patients with different hematological malignancies. Our results revealed that, immediately after autoHSCT, NK cells transiently acquired a decidual-like phenotype, displayed a more immature and activated state, and exhibited an upregulation of inhibitory receptors and a downregulation of activating receptors. This decidual-like and activated phenotype was characterized by increased expression of CD56, CD9, CD49a, CD151, CD38 and HLA-DR. Additionally, we assessed plasma cytokine levels and identified associations between cytokine concentrations and NK cell phenotypic changes.

Indexed as

Hematologic NeoplasmsHematopoietic Stem Cell TransplantationKiller Cells, NaturalLymphocyte SubsetsAdultAgedCytokinesFemaleHumansImmune ReconstitutionImmunophenotypingMaleMiddle AgedTransplantation, AutologousYoung AdultCytokinesautoHSCTautologous hematopoietic stem cell transplantationCD9GDF-15IL-15LAIR-1NK cellsTGF-β

Identifiers

PMID41126839
PMCPMC12537779

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.