Evidence map›Paper›PMID 41126722›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Chronic ER Stress Triggers Cell-Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia.

Yimin Zhou, Zhenfei Zhong, Peng Hu, Weigang Wang, Ying Song, Na Yang, Fangyan He, Yajie Li, Qi Sa, Yanmei Yang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yimin ZhouInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan, 650500, China.
Zhenfei ZhongInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan, 650500, China.
Peng HuDepartment of Hematology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China.
Weigang WangInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan, 650500, China.
Ying SongInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan, 650500, China.
Na YangInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan, 650500, China.
Fangyan HeInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan, 650500, China.
Yajie LiInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan, 650500, China.
Qi SaDepartment of Hematology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China.
Yanmei YangDepartment of Hematology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China.
Qinmiao SunState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Tonghua YangDepartment of Hematology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China.
Beibei ZhangInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan, 650500, China.
Dahua ChenInstitute of Biomedical Research, Yunnan University, Kunming, Yunnan, 650500, China.ORCID https://orcid.org/0000-0002-2122-9141

Funding

Basic Science Center Program of NSFC 31988101Excellence Research Group Program of NSFC 32588201NSFC 82260038Yunnan Province Science and Technology Department 202105AB160002Yunnan Province Science and Technology Department 202201AT070198Yunnan Province Science and Technology Department 202305AS350022Yunnan Province Science and Technology Department 202305AT350003Yunnan Province Science and Technology Department 202501AT070207
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a heterogeneous malignancy with low survival rates, primarily due to its inherent complexity. This underscores the urgent need to identify specific targets for precision medicine. Here, multi-omics approaches are utilized and discover that AML cells undergo chaperone-mediated chronic endoplasmic reticulum (ER) stress. Through integrative analyses of single-cell RNA-seq, cell-surface proteomes, and cellular biology, ER chaperone proteins (e.g., HSP90B1 and P4HB) are identified as potential neoantigens that translocate to the cell surface upon chronic ER stress. These results suggest that these proteins, especially in FLT3-ITD

Indexed as

Endoplasmic Reticulum StressImmunotherapy, AdoptiveLeukemia, Myeloid, AcuteMolecular ChaperonesReceptors, Chimeric AntigenAnimalsCell Line, TumorHSP90 Heat-Shock ProteinsHumansKiller Cells, NaturalMiceHSP90 Heat-Shock ProteinsMolecular ChaperonesReceptors, Chimeric Antigenacute myeloid leukemiacell surface chaperonechimeric antigen receptorchronic ER stressimmunotherapynatural killer cell

Identifiers

PMID41126722
PMCPMC12849903

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.