SynthesisOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2026
Fluorescent Imaging in Thyroid Surgery to Preserve Parathyroid Function: A Systematic Review and Meta-Analysis.
Synthesis in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Indocyanine green (ICG) guided thyroidectomy versus conventional thyroidectomy and the impact on parathyroid function preservation: an updated GRADE-assessed systematic review and meta-analysis.Langenbeck's archives of surgery · 2026Pooled it
- Illuminating the future: assessing probe-based near-infrared autofluorescence for parathyroid detection in endocrine surgery.Gland surgery · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHypoparathyroidism and postoperative hypocalcemia are rare but dreaded complications of thyroid surgery, often requiring increased follow-up and contributing to financial and quality-of-life burdens. This systematic review evaluates the effectiveness of intraoperative fluorescent imaging of parathyroid glands (PGs) in improving PG identification and reducing iatrogenic complications during thyroid surgery. DATA SOURCE: Pubmed, Scopus, CINAHL. REVIEW
methodsA systematic search of PubMed, Scopus, CINAHL, and Cochrane databases was conducted per PRISMA guidelines. Studies using intraoperative fluorescent imaging for PG identification and reporting postoperative calcium and parathyroid hormone (PTH) levels were included. Data on patient demographics, surgical technique, imaging modality, PG identification rates, incidental parathyroidectomy, autotransplantation, and postoperative calcium/PTH outcomes were extracted. Meta-analyses of proportions, odds ratios, and mean differences were performed using MedCalc and Cochrane Review Manager.
resultsTwenty-eight studies (n = 3876) were included. Fluorescent imaging significantly improved PG identification rates (86.4% vs 70.6%, P < .0001) and reduced incidental parathyroidectomy (5.3% vs 9.5%, P = .0017). Short-term hypoparathyroidism (16.7% vs 27.0%, P = .0004) and postoperative hypocalcemia rates on Day 1 (10.6% vs 18.1%, P = .0016) and in the short term (5.7% vs 11.5%, P = .0001) were significantly lower in the fluorescent imaging group. Odds of transient hypocalcemia were also reduced (OR 0.37, P < .00001).
conclusionFluorescent imaging in thyroid surgery significantly improves PG identification rates and reduces the incidence of postoperative hypocalcemia and hypoparathyroidism. Integrating intraoperative fluorescent imaging into the intraoperative thyroid surgery paradigm may enhance patient outcomes by minimizing the frequency of PG-associated complications.
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