ArticleNanomedicine (London, England)2026
Peptide nucleic acid-based biosensor for detection of
Article in Nanomedicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsThis study aimed to develop a rapid and highly sensitive electrochemical biosensor for the sequence-specific detection of Escherichia coli 16S rRNA using a peptide nucleic acid (PNA) probe immobilized on a graphene - NH/gold-nanoparticle (GNH - AuNP) composite. MATERIALS &
methodsAn SH-terminated PNA probe was covalently attached to a GNH - AuNP nanocomposite layer deposited on gold screen-printed electrodes via 3-mercaptopropionic acid (MPA). The electrode assembly and hybridization processes were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and X-ray photoelectron spectroscopy (XPS). Quantification was achieved using differential pulse voltammetry (DPV) with hexaammineruthenium(III) (RuHex) as an electrostatic redox indicator.
resultsHybridization of the target 16S rRNA sequence produced a distinct "signal-on" DPV response proportional to target concentration. The biosensor exhibited excellent linearity from 1 to 1000 pM (R
conclusionsThe PNA/GNH - AuNP interface enabled fast, stable, and highly sensitive E. coli detection. Its disposable electrode format and portable electrochemical readout make it suitable for on-site diagnostic and food-safety monitoring applications.
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