Evidence map›Paper›PMID 41126665›Full record

ArticleEuropean eating disorders review : the journal of the Eating Disorders Association2026

Identifying Distinct Latent Profiles of Executive Functioning Among Adolescents and Adults With Anorexia Nervosa and Adolescent Healthy Controls.

Jiana Schnabel, Marita Cooper, Kristin Stedal, Mark Rose, Betteke Maria van Noort, Deborah A G Drabick, Lauren B Alloy, C Alix Timko

Abstract read
In one paragraph

Article in European eating disorders review : the journal of the Eating Disorders Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiana SchnabelDepartment of Psychology and Neuroscience, Temple University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3260-8822
Marita CooperDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-3822-5809
Kristin StedalRegional Department of Eating Disorders, Division of Mental Health and Addiction, Oslo University Hospital, Ullevål HF, Oslo, Norway.ORCID https://orcid.org/0000-0003-3078-3758
Mark RoseDorset HealthCare University NHS Foundation Trust, Dorset, UK.
Betteke Maria van NoortDepartment of Psychology, MSB Medical School Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-9768-3383
Deborah A G DrabickDepartment of Psychology and Neuroscience, Temple University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-5645-9158
Lauren B AlloyDepartment of Psychology and Neuroscience, Temple University, Philadelphia, Pennsylvania, USA.
C Alix TimkoDepartment of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-2927-7527

Funding

Shifting Perspectives: Enhancing outcomes in adolescent anorexia nervosa with cognitive remediation therapyR33MH119262 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI TIMKO, C. ALIX · 2021 to 2023
$2.4M
Shifting Perspectives: Enhancing outcomes in adolescent anorexia nervosa with cognitive remediation therapyR61MH119262 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI TIMKO, C. ALIX · 2019 to 2020
$1.4M
Foerderer Award from the Research Institute at Children's Hospital of PhiladelphiaHilda and Preston Davis FoundationNIMH NIH HHS R33 MH119262NIMH NIH HHS R33MH119262NIMH NIH HHS R61 MH119262NIMH NIH HHS R61MH119262
6 · The paper itself

Abstract

objectiveResearch suggests executive functioning (EF) inefficiencies contribute to anorexia nervosa (AN) onset and maintenance. Identifying EF subtypes in adolescents and adults with AN compared to healthy controls (HC) may provide insights into differences in illness severity, risk for prolonged illness, and highlight who could respond best to different treatments.

methodWe conducted secondary analysis of 751 participants: adolescents (n = 559) and adults with AN (n = 74), and adolescent HC (n = 118). Latent profiles of six Delis Kaplan Executive Function System scores measuring EF constructs implicated in AN were derived. Differences across profiles on demographics, eating disorder cognitions (EDE/EDE-Q score), BMI/BMI z-score, length of illness, weight suppression, and full-scale IQ were examined.

resultsA three-profile solution best fit the data: Profile 1 (n = 324)-'high verbal', Profile 2 (n = 349)-'average', and Profile 3 (n = 78)-'low flexibility and inhibition'. The low flexibility and inhibition profile comprised 10.6% of adolescents with AN, 30.0% of adults with AN, and 1.7% of adolescent HCs. Compared to other profiles, this profile was older, had a longer illness duration, higher EDE global scores, lower BMI z-scores, and lower full-scale IQ scores. No profile differences emerged in BMI or EDE-Q global scores. DISCUSSION: Only a small subset of our sample showed marked difficulties in flexibility and inhibition, challenging the notion that EF difficulties are a core feature of AN. Adolescents with AN in this profile showed greater illness severity, suggesting vulnerability to a more prolonged course of illness. These findings are a first step towards developing tailored treatment strategies based on EF profiles.

Indexed as

Anorexia NervosaExecutive FunctionAdolescentAdultCase-Control StudiesFemaleHumansMaleNeuropsychological TestsYoung Adultadolescentsanorexia nervosadevelopmentexecutive functioninglatent profile analysis

Identifiers

PMID41126665
PMCPMC12862544

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.