Trial reportMedical science monitor : international medical journal of experimental and clinical research2025
Role of Clinical Pharmacists in Antimicrobial Therapy for Patients with Septic Shock in the ICU.
Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Septic shock is a critical condition frequently encountered in intensive care units (ICUs), characterized by severe infection, systemic inflammation, and hemodynamic instability. This study aimed to evaluate the impact of clinical pharmacist intervention on the optimization of antimicrobial therapy in ICU patients with septic shock. MATERIAL AND METHODS A total of 94 patients with septic shock treated in the ICU between May 2021 and June 2023 were randomly assigned into 2 groups using the envelope method. The control group received standard anti-infective therapy, while the observation group received pharmacist-guided therapy. Treatment continued for 2 weeks. Outcomes assessed included antibiotic utilization patterns, markers of tissue oxygen metabolism (ScvO₂, Lac), inflammatory cytokines (IL-1ß, PCT), and incidence of adverse drug reactions (ADRs). RESULTS The observation group had significantly lower usage rates of carbapenems (23.40%) and quinolones (10.64%) and a higher usage rate of third-generation cephalosporins (34.04%) compared to the control group (P<0.05). ScvO2 was significantly higher, while Lac, IL-1ß, and PCT levels were significantly lower in the observation group after treatment (P<0.05 for all). ADR incidence was lower in the observation group (4.26%) than in the control group (19.15%) (P<0.05). CONCLUSIONS Clinical pharmacist intervention significantly improves the rational use of antibiotics, enhances tissue oxygenation, reduces systemic inflammation, and improves medication safety in ICU patients with septic shock. These findings support broader integration of clinical pharmacists into ICU antimicrobial management protocols.
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