Evidence map›Paper›PMID 41126439›Full record

ArticleJournal of cellular and molecular medicine2025

RTP4 Suppresses Colorectal Cancer Progression via MHC-I-Mediated CD8

Chengpeng Yu, Yifan Li, Zhenzhe Liu, Wen Ye, Lin Wei, Weiqi Xu, Likun Yan, Haifeng Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. RTP4 Suppresses Colorectal Cancer Progression via MHC-I-Mediated CD8Journal of cellular and molecular medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chengpeng YuDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yifan LiClinical College, Nanchang Medical College, Nanchang, China.
Zhenzhe LiuDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Wen YeDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Lin WeiDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Weiqi XuDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Likun YanDepartment of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Haifeng YeMedical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital, School of Basic Medical Sciences, Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China.ORCID 0000-0001-6762-7260

Funding

National Natural Science Foundation of China 82402919National Natural Science Foundation of China 82572888
6 · The paper itself

Abstract

While RTP4 is known to regulate odorant receptor trafficking, its role in colorectal cancer (CRC) remains unclear. This study investigates the clinical relevance and functional mechanisms of RTP4 in CRC. Comprehensive analyses revealed significant downregulation of RTP4 expression in CRC tissues, correlating with poor patient prognosis. RTP4 expression showed strong associations with immune-related genes, biological processes and anti-tumour immune cell infiltration. Mechanistic studies demonstrated that RTP4 upregulates MHC-I expression, which enhances CD8

Indexed as

CD8-Positive T-LymphocytesColorectal NeoplasmsHistocompatibility Antigens Class IImmunotherapyLymphocytes, Tumor-InfiltratingAnimalsCell Line, TumorDisease ProgressionFemaleGene Expression Regulation, NeoplasticHigh Mobility Group ProteinsHumansMaleMicePrognosisHigh Mobility Group ProteinsHistocompatibility Antigens Class ITOX protein, humanbiomarkercolorectal carcinomaimmunotherapyRTP4tumour microenvironment

Identifiers

PMID41126439
PMCPMC12544708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.