Evidence map›Paper›PMID 41126423›Full record

ReviewMini reviews in medicinal chemistry2025

Research Progress in Mutagenesis Techniques for

Songlin Fu, Pengfei Du, Zili Feng

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mini reviews in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Songlin FuCollege of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China.ORCID 0009-0002-4713-8448
Pengfei DuCollege of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China.
Zili FengCollege of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the main fermentation product of Aspergillus fumigatus (A. fumigatus), fumagillin is directly related to the gene of A. fumigatus and exhibits a variety of biological activities. However, its clinical application is limited by low yield and toxicity. It is of great significance to improve the yield and safety of fumagillin using A. fumigatus. Currently, research on fumagillin at home and abroad primarily focuses on a single direction and lacks a systematic review of its biosynthesis, structure-activity relationship, and strain modification technology, as well as a comprehensive theoretical framework. This study systematically reviews the biosynthesis mechanism, activity characteristics, and targeted strain modification technology of fumagillin, providing theoretical support for breakthroughs in production, toxicity regulation, and clinical transformation of fumagillin.

Indexed as

Aspergillus fumigatusCyclohexanesFatty Acids, UnsaturatedMutagenesisSesquiterpenesHumansStructure-Activity RelationshipCyclohexanesFatty Acids, UnsaturatedfumagillinSesquiterpenesAspergillus fumigatusbiological activityfermentation.fumagillingenetic engineeringmutagenesis breeding

Identifiers

PMID41126423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.