Evidence map›Paper›PMID 41126412›Full record

ArticleCurrent Alzheimer research2025

Auditory Hallucinations as the First Symptom of Alzheimer´s Disease - A Case Report.

Thea Husing, Arnim Quante

Abstract readCase Reports
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In one paragraph

Article in Current Alzheimer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Thea HusingDepartment of Neurology with Experimental Neurology, Charité - University Medicine, Berlin, Berlin, Germany.ORCID 0009-0006-5022-1671
Arnim QuanteDepartment of Psychiatry and Psychotherapy, Charité - University Medicine, Berlin, Germany.ORCID 0000-0002-1114-5024

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeuropsychiatric symptoms frequently occur in patients with Alzheimer´s disease (AD); apathy, depression, delusions, optical hallucinations, anxiety, and agitation often appear as first symptoms of AD, while auditory hallucinations have never been described as the first symptom. In this case report, we describe a case of a woman who had auditory hallucinations as the first symptom of AD. CASE PRESENTATION: An 85-year-old woman was admitted to our hospital suffering from imperative auditory hallucinations without subjective and minimal objective memory complaints. Further diagnostics with an MRI scan, neuropsychological tests, and an analysis of cerebral spinal fluid were accomplished. AD was confirmed during the hospital stay, suggesting auditory hallucinations as the first symptom of AD. She was temporarily treated with risperidone, which improved the hallucinations.

conclusionAuditory hallucinations in older age could be the first symptom of AD and even occur before cognitive decline.

Indexed as

Alzheimer DiseaseHallucinationsAged, 80 and overAntipsychotic AgentsBrainFemaleHumansMagnetic Resonance ImagingNeuropsychological TestsRisperidoneAntipsychotic AgentsRisperidoneAlzheimer´s diseaseauditory hallucinationscognitive impairments.dementianeuropsychiatric symptomspsychosis

Identifiers

PMID41126412

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.