ArticleThe Journal of international medical research2025
Olfactory impairment after total laryngectomy: A prospective cohort study.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveTotal laryngectomy, a procedure that permanently separates the upper and lower airways and requires patients to breathe through a stoma, significantly impacts olfactory function owing to the lack of nasal airflow. This prospective cohort study aimed to investigate the reduction in olfactory function following total laryngectomy and determine the association between clinical characteristics and olfactory impairment.MethodsA prospective cohort study was conducted among 40 patients (aged 44-82 years) undergoing total laryngectomy at the University Medical Center Ho Chi Minh City, Vietnam, from November 2023 to April 2025. Olfactory ability was assessed before and after surgery using the Sniffin' Sticks test, including threshold, discrimination, and identification components, which were used to calculate a total threshold, discrimination, and identification score. Additionally, clinical characteristics were analyzed for potential associations with olfactory impairment.ResultsPrior to surgery, objective olfactory testing revealed that 82.5% of the patients had normosmia, and 17.5% exhibited hyposmia. Following surgery, all patients experienced olfactory impairment, with 87.5% presenting with complete anosmia. There was a statistically significant decline in olfactory function after total laryngectomy (
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