ArticleJournal of translational medicine2025
Magnetic resonance imaging quantifies causal body compartment effects on metabolic traits via immune phenotypes-a Mendelian randomisation study.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Visceral fat area and visceral-to-subcutaneous fat ratio are more strongly associated with residual cholesterol than conventional anthropometric indices in adults with type 2 diabetes.Frontiers in endocrinology · 2026Article
- Further insights into the causal link between immune cell phenotypes and autoimmune liver diseases.Translational gastroenterology and hepatology · 2026Article
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Abstract
backgroundMetabolic diseases, including type 2 diabetes (T2D), hypertension, hyperlipidemia and metabolic dysfunction-associated fatty liver disease (MAFLD), are globally prevalent. However, traditional measures, such as body mass index (BMI), fail to capture body composition heterogeneity to accurately predict metabolic diseases. Magnetic resonance imaging (MRI) provides a precise quantification of body composition; however, the causal links among these compartments, immune phenotypes, and metabolic traits remain unclear. This Mendelian randomisation (MR) study aimed to investigate the compartment-specific effects of MRI-derived body composition measures on metabolic diseases and assess the mediating role of immune phenotypes.
methodsUsing a two-sample MR framework, genetic instruments for 10 MRI-assessed body composition traits were derived from GWAS data. The outcomes included metabolic diseases (T2D, MAFLD, and hypertension) and glycolipid metabolism traits. Mediation analysis integrated 731 immune cell types. Robustness was assessed using the MR-Egger, Weighted Median, and MR-PRESSO methods, addressing pleiotropy and heterogeneity.
resultsVisceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) exerted strong causal effects on BMI (odds ratio [OR] = 1.136). The strongest causal effect on MAFLD risk was observed for liver proton density fat fraction (LPDFF) (OR = 1.833). VAT, weight-muscle ratio and ASAT positively influenced levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol, whereas they negatively influenced triglyceride levels. Immune phenotypes mediated 28 causal pathways: ectopic fat promoted pro-inflammatory immune profiles, transitional B cells and Memory-CD8
conclusionOur study emphasised the correlation between MRI-derived body composition measures and metabolic diseases, particularly revealing VAT, subcutaneous adipose tissue, and liver proton density fat fraction as key causal drivers of metabolic diseases while uncovering the pivotal role of immune phenotypes in mediating these metabolic pathways. These findings support the integration of MRI-based body composition profiling into clinical screening for metabolic diseases of high-risk cohorts, and provide a novel theoretical foundation for immune-targeted therapies to combat metabolic dysregulation.
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