ArticleLipids in health and disease2025
Triglyceride-glucose (TyG) index combined with C-reactive protein outperforms the TyG index alone in predicting stroke in arthritis patients: a nationwide prospective cohort study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Long-term cumulative exposure and change patterns of CTI-FI predict the risk of cardiometabolic multimorbidity in middle-aged and older Chinese adults.Journal of diabetes and metabolic disorders · 2026Article
- The C-Reactive Protein-Triglyceride-Glucose Index and Functional Outcomes in Acute Ischemic Stroke Patients Following Endovascular Thrombectomy.Brain and behavior · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundArthritis patients exhibit a higher stroke risk, but effective predictive biomarkers are scarce. This research sought to examine and compare the associations between the triglyceride-glucose (TyG) index, its integration with C-reactive protein (CRP) (TyG-CRP), and stroke risk in these patients.
methodsThis research examined data from 3,419 arthritis patients participating in the China Health and Retirement Longitudinal Study (CHARLS), focusing on the occurrence of new stroke events as the main outcome. Examination of the association between the TyG index, TyG-CRP and stroke risk relied on Kaplan-Meier, Cox regression, and restricted cubic splines (RCS) analyses.
resultsDuring the 9-year follow-up period, 339 arthritis patients (9.9%) had their initial stroke. Stroke incidence increased steadily from the lowest to highest tertile categories as determined by both TyG index and TyG-CRP (P < 0.05). After full covariate adjustment, each 1-unit increment in TyG-CRP raised stroke risk by 18% (HR, 1.18; 95% CI, 1.01-1.39), and individuals in the top TyG-CRP tertile were 1.4 times more likely to experience a stroke versus those in the bottom tertile (HR, 1.40; 95% CI, 1.03-1.92). There was no significant link between the TyG index and stroke risk, whether it was assessed continuously or by tertiles (P > 0.05) in the fully adjusted models. TyG-CRP was significantly linearly related to stroke incidence (P-overall: 0.047; P-nonlinear: 0.725), whereas the TyG index, although linear, also demonstrated an insignificance (P-overall: 0.165; P-nonlinear: 0.557). In sensitivity analyses conducted among complete cases, TyG-CRP demonstrated borderline statistical significance for stroke risk in the model with comprehensive covariate adjustment (P = 0.058 for the continuous variable analysis; P = 0.064 for tertile-based comparisons).
conclusionTyG-CRP is a standalone predictor of stroke in arthritis individuals, whereas the TyG index does not significantly predict stroke risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.