Evidence map›Paper›PMID 41126267›Full record

ArticleRespiratory research2025

Dual-energy computed tomography derived pulmonary blood volume: association with pulmonary blood flow.

Jakob Wittenstein, Rudi Apolle, Martin Scharffenberg, Carolin Rothmann, Sabine Müller, Ralf-Thorsten Hoffmann, Esther G C Troost, Thea Koch, Marcelo Gama de Abreu, Robert Huhle

Abstract read
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In one paragraph

Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jakob Wittenstein *Department of Anaesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, Dresden, 01307, Germany.ORCID http://orcid.org/0000-0003-4397-1467
Rudi Apolle *National Center for Tumor Diseases (NCT), Partner Site, Dresden, Germany.ORCID http://orcid.org/0000-0002-1375-0498
Martin ScharffenbergDepartment of Anaesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, Dresden, 01307, Germany.
Carolin RothmannDepartment of Anaesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, Dresden, 01307, Germany.
Sabine MüllerDepartment of Anaesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, Dresden, 01307, Germany.
Ralf-Thorsten HoffmannInstitute and Policlinic for Diagnostic and Interventional Radiology, University Hospital Carl Gustav Carus Dresden at Technische Universität Dresden, Dresden, Germany.
Esther G C TroostNational Center for Tumor Diseases (NCT), Partner Site, Dresden, Germany.
Thea KochDepartment of Anaesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, Dresden, 01307, Germany.
Marcelo Gama de AbreuDepartment of Anaesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, Dresden, 01307, Germany.
Robert HuhleDepartment of Anaesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Fetscherstraße 74, Dresden, 01307, Germany. robert.huhle@tu-dresden.de.ORCID http://orcid.org/0000-0003-2185-1819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDistribution of ventilation and pulmonary perfusion are the major determinants of pulmonary gas exchange. To study and compare strategies of mechanical ventilation in respiratory research accurate and high-resolution methods are needed to derive distribution of ventilation and perfusion with minimal additional intervention or radiation allowing repeated measurements. Dual-energy computed tomography (DECT) is an imaging technique allowing for the derivation of regional pulmonary perfused blood volume, as a surrogate for pulmonary perfusion (PP

methodsAgreement between PP

resultsRegression analysis revealed a good overall association (R2 = 0.81) between PP

conclusionsDual-energy CT based measurement of pulmonary perfusion shows promising results indicating its feasibility in translational research on strategies of mechanical ventilation.

Indexed as

Blood VolumeLungPulmonary CirculationRadiography, Dual-Energy Scanned ProjectionTomography, X-Ray ComputedAnimalsFeasibility StudiesFemaleSwineDual-energy CTFluorescence labelled microspheresRegional pulmonary perfusionShunt blood flow

Identifiers

PMID41126267
PMCPMC12548200

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.